Effect of Menopause on Interleukin-1 Concentration in Gingival Crevicular Fluids

DOI 2 Citations 43 References
  • Fuma Daisuke
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Inagaki Koji
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Ishihara Yuichi
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Koide Masanori
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Hayashi Junichiro
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Tanaka Shigehisa
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Sobue Takanori
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Ito Takashi
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Iwata Takehisa
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Suzuki Mariyo
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Kurosu Yasunari
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Sato Renzo
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Sakano Masahiro
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Sugiishi Tai
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Yoshinari Nobuo
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University
  • Noguchi Toshihide
    Department of Periodontology, School of Dentistry, Aichi-Gakuin University

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Other Title
  • 閉経が歯肉溝しん出液中のインターロイキン‐１濃度に及ぼす影響

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Estrogen is thought to play a role in inhibiting bone resorption and reduced estrogen levels correlate with postmenopausal osteoporosis. Menopause and oophorectomy have been associated with increased production of bone resorption-inducing cytokines. The purpose of the present study was to compare the concentrations of Interleukin-1 (IL-1) in the gingival crevicular fluid (GCF) of premenopausal and postmenopausal women. IL-1 α, IL-1 β, IL-1 receptor antagonist (ra) and the total IL-1/IL-1 ra ratio (IL-1 activity index ; IL-1 AI) were measured in 144 GCF samples from 72 sites in 12 premenopausal patients (Pr group : age 44.2±2.2) and 72 sites in 12 postmenopausal patients (Po group : age 57.8±1.3). IL-1 α, IL-1 β and IL-1 ra were measured by specific non-crossreactive enzyme linked immunosorbent assays. The probing depth, clinical attachment level, bleeding on probing, tooth mobility, gingival index, and alveolar bone loss of each site were recorded at the time of GCF sampling. The marginal gingival inflammation in both groups was well controlled and the clinical inflammatory assessments of the gingival condition were indistinguishable in both groups. The concentrations of IL-1 α, IL-1 β, IL-1 ra and IL-1 AI in the Po group were significantly higher than those in the Pr group (IL-1 α 110.0±15.1 pg/ml ; 61.3±8.8 pg/ml, P < 0.01, IL-β 27.3±4.8 pg/ml ; 15.6±3.4 pg/ml, P < 0.05, IL-1 ra 77.2±13.6 ng/ml ; 39.9±4.3 ng/ml, P < 0.01, IL-1 AI, 27.3±4.8 pg/ml ; 15.6±3.4 pg/ml, 86951<0.05). Conclusively, the increased IL-1 α, IL-1 β, IL-1 ra concentrations and IL-1 AI in the Po group suggest that menopause does correlate with increased IL-1 cytokine in GCF.

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