歯周疾患と抵抗因子・第1編, 歯周ポッケトにおける抗菌因子の免疫病理学的観察

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  • Periodoal Disease and Resistance Factor, I, Immunopathological Study for Detection of Antibiotic Factors in the Pocket Fluid

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This study was made to clarify the existense of antibiotic factors to oral bacteria in the gingival pocket fluid of individuals with periodontal disease by using fluorescent antibody techniques. Fluorescein-labeled antisera were obtained from human oral bacteria, Clq, C3, properdin, IgG, IgA, IgM, IgD, IgE, Fab, fibrinogen, and serious frozen sections were stained by them.<br>The results were as follows:<br>1) Each substance was detcted in the bacterial mass as showing Table 1 and Fig. 1.<br>2) IgG, IgA, Fab, and fibrinogen were demonstrated most frequently as Fig. 3.<br>From above results, we arrived at following conclusions:<br>1) Main defensive system to the oral bacteria in the gingival pocket were immunoglobulins and activated complement system.<br>2) The complement was the alternative pathway in addition to classical pathway.<br>3) We were suggested that both complement systems raised to activity of phagocytosis, and finally caused to bacterial lysis in the gingival pocket.

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