Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay: Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of P53 on Urinary Bladder Carcinogenesis

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  • Ishii Naomi
    Department of Pathology, Osaka City University Graduate School of Medicine
  • Wei Min
    Department of Pathology, Osaka City University Graduate School of Medicine
  • Kakehashi Anna
    Department of Pathology, Osaka City University Graduate School of Medicine
  • Doi Kenichiro
    Department of Pathology, Osaka City University Graduate School of Medicine
  • Yamano Shotaro
    Department of Pathology, Osaka City University Graduate School of Medicine
  • Inaba Masaaki
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
  • Wanibuchi Hideki
    Department of Pathology, Osaka City University Graduate School of Medicine

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In the present study, modifying effects of diabetes on carcinogenesis induced in type 2 diabetes mellitus model Zucker diabetic fatty (ZDF) rats were investigated using a multiorgan carcinogenesis bioassay. Our results demonstrated enhancement of urinary bladder, colon and liver carcinogenesis in ZDF rats treated with five types of carcinogens (DMBDD). Elevated insulin and leptin and decreased adiponectin levels in the serum may be responsible for the high susceptibility of type 2 diabetes mellitus model rats to carcinogenesis in these organs. Possible mechanisms of increased susceptibility of diabetic rats to bladder carcinogenesis could be activation of the PI3K pathway and suppression of p53 in the urothelium in consequence of the above serum protein alterations.

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