Bilateral Cataract in a Cynomolgus Monkey

DOI Web Site Web Site 被引用文献2件 参考文献37件
  • Sasaki Yuji
    Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.
  • Kodama Rinya
    Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.
  • Iwashige Shuichiro
    Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.
  • Fujishima Junko
    Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.
  • Yoshikawa Tsuyoshi
    Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.
  • Kamimura Yasuhiro
    Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.
  • Maeda Hiroshi
    Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.

この論文をさがす

抄録

Severe bilateral cataract was found in a 7 year-old naïve female cynomolgus monkey (Macaca fascicularis) 3 months before necropsy. During macroscopic examination, severe opacity and thinning of the lens were observed in both eyes. Histopathology revealed that the lens nuclei and majority of cortex lens fibers had disappeared and become excavated, while the lens fibers in the subcapsular area were swollen and distorted. Other observations included atrophy and vacuolation in the lens epithelial cells and proliferation of spindle cells and collagen fiber beneath the anterior capsule of the right eye. Immunohistochemical staining of these spindle cells revealed the presence of vimentin, cytokeratin and α-smooth muscle actin (α-SMA), which were considered to be derived from lens epithelial cells. This is a rare case of spontaneous, bilateral, hypermature cataract in a cynomolgus monkey.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (37)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ