Malignant Mesothelioma in the Thoracic Cavity of a Crj:CD(SD) Rat Characterized by Round Hyalinous Stroma
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- Doi Takuya
- Kashima Laboratory, Mitsubishi Chemical Medience Corporation
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- Kotani Yuri
- Kashima Laboratory, Mitsubishi Chemical Medience Corporation
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- Takahashi Kazuaki
- Kashima Laboratory, Mitsubishi Chemical Medience Corporation
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- Hashimoto Satomi
- Kashima Laboratory, Mitsubishi Chemical Medience Corporation
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- Yamada Naoaki
- Kashima Laboratory, Mitsubishi Chemical Medience Corporation
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- Kokoshima Hiroko
- Kashima Laboratory, Mitsubishi Chemical Medience Corporation
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- Tomonari Yuki
- Kashima Laboratory, Mitsubishi Chemical Medience Corporation
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- Wako Yumi
- Kashima Laboratory, Mitsubishi Chemical Medience Corporation
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- Tsuchitani Minoru
- Kashima Laboratory, Mitsubishi Chemical Medience Corporation
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Abstract
Spontaneous malignant mesothelioma was found in a 104-week-old male Crj:CD(SD) rat. The tumor was scattered on the surface of the lung, heart, mediastinal pleura and thoracic wall and metastasized to the alveolar septa. Histopathologically, small flattened or cuboidal tumor cells proliferated with stroma, formed almost normal papillary structures and reacted positively to colloidal iron stain and immunohistochemical staining for mesothelin. Round hyalinous stromata were pronounced, which is a characteristic feature, and the possible reason for this is as follows; at first, a small amount of collagen fibers was formed in the center of the clusters of several tumor cells, and then the cell clusters expanded like balloons with an increase in the collagen fibers. <br>
Journal
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 23 (2), 103-106, 2010
JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY
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Details 詳細情報について
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- CRID
- 1390282679391941376
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- NII Article ID
- 10030978813
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- NII Book ID
- AN10232280
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- COI
- 1:STN:280:DC%2BC387ntF2nsQ%3D%3D
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- ISSN
- 1881915X
- 09149198
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- NDL BIB ID
- 10756780
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- PubMed
- 22272019
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed