Vacuolar Change in the Thyroid Follicular Cells in BrlHan: WIST@Jcl(GALAS) Rats.

DOI Web Site 被引用文献12件 参考文献6件 オープンアクセス
  • Shimoi Akihito
    Pharmacology Laboratory, Reserch Center, Mochida Pharmaceutical Co., Ltd.
  • Kuwayama Chitose
    Toxicology Laboratory, Reserch Center, Mochida Pharmaceutical Co., Ltd.
  • Miyauchi Makoto
    Toxicology Laboratory, Reserch Center, Mochida Pharmaceutical Co., Ltd.
  • Kakinuma Chihaya
    Toxicology Laboratory, Reserch Center, Mochida Pharmaceutical Co., Ltd.
  • Kamiya Masatsugu
    Pharmacology Laboratory, Reserch Center, Mochida Pharmaceutical Co., Ltd.
  • Harada Tsuyoshi
    Toxicology Laboratory, Reserch Center, Mochida Pharmaceutical Co., Ltd.
  • Ogihara Takuo
    Pharmacology Laboratory, Reserch Center, Mochida Pharmaceutical Co., Ltd.
  • Kurokawa Misao
    Pharmacology Laboratory, Reserch Center, Mochida Pharmaceutical Co., Ltd.
  • Mizuguchi Kiyoshi
    Pharmacology Laboratory, Reserch Center, Mochida Pharmaceutical Co., Ltd.

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説明

Huge vacuoles in the follicular epithelial cells distributing diffusely in the thyroid gland were seen in 2 out of 36 males and 8 out of 82 females of BrlHan: WIST@Jcl (GALAS) rats examined histopathologically. The vacuoles showed negative reactivity by periodic acid-Schiff reaction and thyroglobulin-immunohistochemistry. Corresponding to the vacuoles, remarkable dilatation of rough endoplasmic reticulum was seen in electron microscopic observation. The animals in which the thyroid lesion was found had shown no abnormalities in behavior, body weight, food consumption, or hematological and biochemical examinations. Plasma concentrations of thyroid-stimulating hormone (TSH) and thyroid hormones (T3 and T4) were not different from those of normal rats. From these results, thyroid functions seemed to be kept normal in spite of the severe morphological change. Based on the character and incidence of the thyroid lesion, it was presumed to be related with a certain genetic factor of one or several parents of breeding rats rather than food contamination or infection.

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