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- Kobayashi Kinji
- Drug Safety Research Laboratories, TANABE Seiyaku Co., Ltd.
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- Fujiwara Toshihisa
- Drug Safety Research Laboratories, TANABE Seiyaku Co., Ltd.
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- Adachi Tamiko
- Drug Safety Research Laboratories, TANABE Seiyaku Co., Ltd.
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- Asahina Masatoshi
- Drug Safety Research Laboratories, TANABE Seiyaku Co., Ltd.
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- Sasaki Yoshifumi
- Drug Safety Research Laboratories, TANABE Seiyaku Co., Ltd.
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- Matsuda Aoi
- Drug Safety Research Laboratories, TANABE Seiyaku Co., Ltd.
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- Nishimura Tomonari
- Drug Safety Research Laboratories, TANABE Seiyaku Co., Ltd.
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- Inui Toshihide
- Drug Safety Research Laboratories, TANABE Seiyaku Co., Ltd.
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- Kitamura Kazuyuki
- Drug Safety Research Laboratories, TANABE Seiyaku Co., Ltd.
この論文をさがす
抄録
We report a case of bilateral ovotestes in a female beagle dog. This dog was used in a 4-week repeated-dose toxicity study and sacrificed by exsanguination at 6 months of age. Clinical observation, hematological examination, blood chemistry analysis, urinalysis and autopsy did not reveal any abnormal or drug-induced effects. Microscopically, seminiferous-like tissue was observed in the medulla of the bilateral ovaries. The morphological and immunohistochemical characteristics of Sertoli-like cells lining the seminiferous-like tubules corresponded to those of Sertoli cells in the testis. Myoid-like cells exhibiting positive reactions for alpha smooth muscle actin surrounded the seminiferous-like tubules. Therefore, the dog was regarded as a case of true hermaphroditism with bilateral ovotestes. PCR using DNA extracted from paraffin-embedded sections of the testicular parts of the ovotestis, uteri and spleen showed that the organogenesis of ovotestes in this case was not associated with the sex-determining region Y gene.
収録刊行物
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 20 (2), 111-115, 2007
日本毒性病理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679392613120
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- NII論文ID
- 10025854250
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- NII書誌ID
- AN10232280
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- ISSN
- 1881915X
- 09149198
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- NDL書誌ID
- 8883529
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可