Unusual Lipomatous Lesion with Extramedullary Hematopoiesis Possibly Derived from Ito (Perisinusoidal) Cells in a CD-1 Mouse
-
- Kotani Yuri
- Mitsubishi Chemical Safety Institute Ltd.
-
- Kurotaki Tetsuro
- Mitsubishi Chemical Safety Institute Ltd.
-
- Doi Takuya
- Mitsubishi Chemical Safety Institute Ltd.
-
- Wako Yumi
- Mitsubishi Chemical Safety Institute Ltd.
-
- Tsuchitani Minoru
- Mitsubishi Chemical Safety Institute Ltd.
この論文をさがす
抄録
A grayish white nodule, 1.0 × 1.0 × 2.0 cm in size, was grossly observed in the liver of a 110-week-old male CD-1 mouse. Microscopically, the lesion was characterized by two types of proliferation area, one of which was composed of a lipomatous proliferation with small spindle cells and severe extramedullary hematopoiesis (EMH). The other area was composed of large spindle cells closely proliferating along the hepatic cords. The proliferative lesion was partly positive for vimentin and had increased amounts of laminin, which is an extracellular matrix protein synthesized by Ito cells. Ultrastructurally, the lipomatous area contained cells with individual lipid droplets in the cytoplasm. The characteristic findings of this nodule were similar to those of Ito cell tumors in mice reported previously, except for the severe EMH in our case.
収録刊行物
-
- Journal of Toxicologic Pathology
-
Journal of Toxicologic Pathology 20 (2), 105-109, 2007
日本毒性病理学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679392614656
-
- NII論文ID
- 10025854237
-
- NII書誌ID
- AN10232280
-
- ISSN
- 1881915X
- 09149198
-
- NDL書誌ID
- 8883520
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可