Testicular Mineralization in KK-A[y] Mice Treated with an Oxovanadium Complex
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- MOROKI Takayasu
- Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan
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- YOSHIKAWA Yutaka
- Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan
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- YOSHIZAWA Katsuhiko
- Department of Pathology II, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 573-1010, Japan
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- TSUBURA Airo
- Department of Pathology II, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 573-1010, Japan
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- YASUI Hiroyuki
- Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan
書誌事項
- タイトル別名
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- Testicular Mineralization in KK-A<sup>y</sup> Mice Treated with an Oxovanadium Complex
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Vanadium has potential for use in diabetes therapy. Many investigators have reported toxic effects of inorganic vanadium salts; however, there are few reports on toxic effects of oxovanadium(VO2+) complexes. Therefore, we studied VO2+ toxicity by examining histological changes and measuring the vanadium concentration in the testis after repeated oral administration of bis(1-oxy-2-pyridine-thiolato)oxovanadium(VO2+) (VO(opt)2) for 2 or 4 weeks in KK-Ay mice. Severe mineralization and degeneration/necrosis of the seminiferous tubules were detected after either 2 or 4 weeks of administration. Vacuolar changes in Sertoli cells and the seminiferous epithelia, and hyperplasia of Leydig cells were observed in the testes of some animals. Vanadium concentrations in the mineralized testis were much higher than those in the testis of untreated KK-Ay mice. These results represent the first report of the possibility for seminiferous tubules mineralization induced by VO(opt)2 administration. Therefore, our research provides important information about the potentially toxic effects of VO2+ complexes.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｔｏｘｉｃｏｌｏｇｉｃ Ｐａｔｈｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｔｏｘｉｃｏｌｏｇｉｃ Ｐａｔｈｏｌｏｇｙ 26 (3), 329-333, 2013
日本毒性病理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679392647680
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- NII論文ID
- 130003382451
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- NII書誌ID
- AN10232280
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- COI
- 1:CAS:528:DC%2BC3sXhslyrs7jN
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- ISSN
- 1881915X
- 09149198
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- NDL書誌ID
- 024937385
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- PubMed
- 24155568
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- 本文言語コード
- en
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- データソース種別
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- NDL
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- PubMed
- CiNii Articles
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- 使用不可