Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset (Callithrix jacchus)

YAMAGUCHI Itaru, MYOJO Kensuke, SANADA Hiroko, SUDO Eri, OOTSUKA Sayaka, OKUMURA Hiroshi, TAKAMI Atsuko, YONESHIGE Tomomi, SUZUKI Yui, IMAIZUMI Minami, TAKADA Chie, KIMOTO Naoya, SAEKI Koji, TAKABA Katsumi

doi:10.1293/tox.26.301

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Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset (<i>Callithrix jacchus</i>)

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We histopathologically and immunohistochemically investigated a case of malignant lymphoma that spontaneously developed in a male common marmoset at two years of age. Beginning at two years four months of age, the animal had an enlargement of the submandibular and inguinal lymph nodes, small subcutaneous nodules near the right breast and an approximately fivefold increase in peripheral lymphocyte count compared with the previous examination value. The postmortem findings at two years eight months of age showed lymphadenopathy with enlargement of the thymus and spleen. Small- to intermediate-sized neoplastic lymphocytes had diffusely proliferated in the enlarged nodes. The neoplastic cells were pleomorphic and had irregularly shaped nuclei. The nuclear chromatin staining revealed hyperchromatism in the small-sized cells, and the intermediate-sized cells exhibited vesicular staining. An immunohistochemical examination indicated that the neoplastic lymphocytes were positive for CD3 and negative for CD20, thus suggesting that they had originated from T cells. In addition, the proliferation of high endothelial venules and reactive epithelioid histiocytes was observed. Scattered tingible body-laden macrophages were infrequently detected. Neoplastic lymphocytes were also observed in the thymus, spleen, heart, lungs, liver, kidneys, adrenal glands and femoral and sternal bone marrow. This malignant lymphoma in a young male common marmoset was considered to fit the category of “peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)” according to the new WHO system of classification.

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Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ

Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ 26 (3), 301-307, 2013

日本毒性病理学会

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CRID: 1390282679392653312

NII論文ID: 130003382444

NII書誌ID: AN10232280

DOI: 10.1293/tox.26.301

COI: 1:STN:280:DC%2BC2c%2FpsV2lsQ%3D%3D

ISSN: 1881915X; 09149198

NDL書誌ID: 024937253

PubMed: 24155563

Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024937253; https://www.jstage.jst.go.jp/article/tox/26/3/26_2012-0046/_pdf; https://search.jamas.or.jp/link/ui/2014183133

本文言語コード: en

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Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset (Callithrix jacchus)

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Spontaneous Malignant T Cell Lymphoma in a Young Male Common Marmoset (Callithrix jacchus)

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収録刊行物

被引用文献 (2)*注記

参考文献 (28)*注記

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