Superoxide dismutaseのパラコート誘発によるラットのDiffuse alveolar damageに対する保護作用についての病理組織学的,組織計測学的および超微形態学的研究

DOI Web Site
  • 林 幹人
    日本化薬株式会社医薬事業本部総合研究所安全性研究所
  • 吉兼 崇彦
    日本化薬株式会社医薬事業本部総合研究所安全性研究所
  • 市村 英資
    日本化薬株式会社医薬事業本部総合研究所安全性研究所
  • 横山 武
    自治医科大学病理学教室

書誌事項

タイトル別名
  • Histopathological, histometrical and ultrastructural studies in protective effects of superoxide dismutase against diffuse alveolar damage of the rats induced by paraquat.

この論文をさがす

説明

Histopathological, histometrical and ultrastructural changes in protective effects of recombinant human Cu, Zn-superoxide dismutase (SOD) against diffuse alveolar damage (DAD) of the male rats induced by paraquat were studied. The animals were given a single intraperitoneal injection of 25mg/kg body weight of paraquat, followed by a single intraperitoneal injection of 46, 000U/kg body weight of SOD at 1 and 7 hour after paraquat injection for SOD group. In contrast an equal volume of saline was injected instead of SOD for the control group. Difference in results between SOD and control groups was early and late phase effects. In the early phase effects, pulmonary congestion was suppressed from 2 hours after paraquat injection and edematous swelling of type I alveolar epithelia was significant even 24 hours after paraquat injection in the SOD group. In the late phase effects, proliferative changes of alveolar epithelium and interstitium in the SOD group were decreased. From these results, it is supposed that 1) paraquat-induced DAD is alleviated by SOD treatment which results in a scavenger of the superoxide radical and suppression of secondary inflammation by paraquat injection, and 2) SOD treatment may be an effective treatment for paraquat toxicity.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ