Establishment of a mouse model for pulmonary inflammation and fibrosis by intratracheal instillation of polyhexamethyleneguanidine phosphate

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  • Lee Sang Jin
    Department of Biochemistry, College of Medicine, Konyang University, 158 Gwanjeodong-ro, Seo-gu, Daejeon 302-718, Republic of Korea Inhalation Toxicology Center, Korea Institute of Toxicology, 30 Baekhak 1-Gil, Jeongeup-si, Jeollabuk-do 580-185, Republic of Korea
  • Park Jong-Hwan
    Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, 77 Yongbong-ro, Buk-gu , Gwangju 61186, Republic of Korea
  • Lee Jun-Young
    Department of Biochemistry, College of Medicine, Konyang University, 158 Gwanjeodong-ro, Seo-gu, Daejeon 302-718, Republic of Korea
  • Jeong Yu-Jin
    Department of Biochemistry, College of Medicine, Konyang University, 158 Gwanjeodong-ro, Seo-gu, Daejeon 302-718, Republic of Korea
  • Song Jeong Ah
    Inhalation Toxicology Center, Korea Institute of Toxicology, 30 Baekhak 1-Gil, Jeongeup-si, Jeollabuk-do 580-185, Republic of Korea
  • Lee Kyuhong
    Inhalation Toxicology Center, Korea Institute of Toxicology, 30 Baekhak 1-Gil, Jeongeup-si, Jeollabuk-do 580-185, Republic of Korea Toxicology and Pharmacology, University of Science and Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 305-350, Republic of Korea
  • Kim Dong-Jae
    Laboratory Animal Resource Center, Daegu Gyeongbuk Institute of Science & Technology (DGIST), 333 Techno Jungang Daero, Hyeonpung-myeon, Dalseong-gun, Daegu 42988, Republic of Korea

書誌事項

公開日
2016
DOI
  • 10.1293/tox.2015-0067
公開者
日本毒性病理学会

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説明

Although several animal models have been developed to study human pulmonary fibrosis, lack of a perfect model has raised the need for various animal models of pulmonary fibrosis. In this study, we evaluated the pulmonary effect of polyhexamethyleneguanidine phosphate instillation into the lungs of mice to determine the potential of these mice as a murine model of pulmonary fibrosis. Intratracheal instillation of polyhexamethyleneguanidine phosphate induced severe lung inflammation manifested by the infiltration of mononuclear cells and neutrophils and increased production of IL-6, TNF-α, CCL2 and CXCL1. The lung inflammation gradually increased until 28 days after polyhexamethyleneguanidine phosphate exposure, and increases of collagen deposition and TGF-β production, which are indicators of pulmonary fibrosis, were seen. Our study showed that intratracheal instillation of polyhexamethyleneguanidine phosphate induces pulmonary inflammation and fibrosis in mice.

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