Aneugenic effects of carbendazim and griseofulvin as assayed in the in vitro maturation system of mouse oocytes

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  • Tanaka Ryota
    Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center) United Graduate School of Agricultural Science, Gifu University
  • Sasanami Tomohiro
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • Toriyama Masaru
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • Mizuhashi Fukutaro
    Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center)
  • Mori Makoto
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University

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To evaluate the aneugenic effects of carbendazim (MBC) and griseofulvin (GF) on meiosis, we cultured mouse oocytes, allowing them to mature in vitro in the presence of MBC and GF. The incidence of hyperploidy was significantly increased in oocytes cultured with 0.6 μg/mL or higher concentration of MBC, while the incidence of diploidy was significantly increased in oocytes cultured with 1 or 3 μg/mL of GF. To investigate the stage-specific effects of these chemicals during meiotic progression, the oocytes were exposed to chemicals for the initial 7 h or final 8 h of the culture. Both MBC and GF were found to effectively induce numerical aberration during the final half of the culture. Thus, in vitro maturation of mouse oocytes is a useful model for the detection of chemically induced aneuploidy and for the detection of stage-specific effects of chemicals during meiosis.

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