Validation of an Analytical Method for the Simultaneous Determination of Iminoctadine, Diquat, and Paraquat in Drinking Water Using SPE-LC/MS/MS

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  • 水道水中のイミノクタジン・ジクワット・パラコートLC/MS/MS一斉分析法の妥当性評価
  • スイドウ スイチュウ ノ イミノクタジン ・ ジクワット ・ パラコート LC/MS/MS イッセイ ブンセキホウ ノ ダトウセイ ヒョウカ

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Abstract

<p>In order to confirm the validity of a solid-phase extraction (SPE) - liquid chromatography/tandem mass spectrometry (LC/MS/MS) analytical method for the simultaneous determination of iminoctadine, diquat, and paraquat in drinking water, a validation test was conducted by 12 organizations. Recovery tests of these agricultural chemicals in drinking water obtained by each organization were performed in two set points (0.5 and 0.05 μg/L), which are 1/10 and 1/100 of target values of diquat and paraquat. Linearity of calibration curves, selectivity, accuracy (recovery), repeatability, and intermediate precision of each agricultural chemical were calculated by the data of the recovery tests. Linearity of calibration curves and selectivity were satisfactory in these 3 agricultural chemicals. Accuracy, repeatability, and intermediate precision for diquat and paraquat obtained by the recovery tests were satisfied with the criteria in the guideline for validation of testing method in drinking water, which has been notified by the Ministry of Health, Labour and Welfare, Japan. Therefore, we concluded that the analytical method is valid for the analysis of diquat and paraquat in drinking water. In contrast, accuracy and repeatability, and intermediate precision for iminoctadine were not satisfied with the criteria in the guideline in some organizations due to the highest adsorbability among 3 chemicals. Therefore, analysis of iminoctadine by the analytical method requires especial care in pretreatment.</p>

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