CANCER-SUPPRESSING EFFECT OF ACETYL FUCOIDAN DERIVED FROM OKINAWA MOZUKU (Cladosiphon okamuranus TOKIDA)

DOI 14 References
  • ISHIWATA Kazuo
    Physiology Department, Tokai University School of Medicine, Isehara, Japan
  • SHIZUMA Toru
    Physiology Department, Tokai University School of Medicine, Isehara, Japan
  • NAKAZAWA Hiroe
    Physiology Department, Tokai University School of Medicine, Isehara, Japan
  • MORI Hidezo
    Department of Cardiac Physiology, National Cardiovascular Center
  • FUKUYAMA Naoto
    Physiology Department, Tokai University School of Medicine, Isehara, Japan

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Other Title
  • 沖縄モズク由来アセチルフコイダンの癌抑制効果

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Purpose: Fucoidan, a substance contained in seaweeds, has a wide range of useful biological activities, but the effects of acetyl fucoidan derived from Okinawa mozuku (Cladosiphon okamuranus TOKIDA) on cancer have not been investigated. In this study we evaluated the cancer-suppressing effects of acetyl fucoidan derived from Okinawa mozuku. <BR>Material and Methods: As an animal experiment model, a model of implanted mouse colorectal cancer cells was used. Following the implantation of the cancer cells, the experimental subjects were given tap water (control) or water containing 5% acetyl fucoidan. Changes in the mean body weight over time were measured, and tumor volume was measured. After the excision of the tumor tissues, histochemical examination was used to investigate the infiltration of the tumors and the presence or absence of apoptotic cells. <BR>Results and discussion: A statistically significant weight loss suppression effect was found in the fucoidan group, and tumor volume was statistically significantly reduced in the fucoidan group. Histochemically as well, tumor infiltration was found to be inhibited in the fucoidan group, and apoptotic cells were observed. <BR>Conclusions: Acetyl fucoidan derived from Okinawa mozuku was found to induce apoptosis in cancer cells and suppress tumor growth.

Journal

  • Jomyaku Keicho Eiyo

    Jomyaku Keicho Eiyo 22 (4), 489-495, 2007

    Japanese Society for Parenteral and Enteral Nutrition

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