Successful treatment of unresectable salivary duct carcinoma of submandibular gland with heavy ion radiotherapy

DOI 4 References
  • Onoda Tomoo
    Department of Otoralyngology,Head and Neck Surgery Okayama University hospital Head and Neck cancer centerOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Makino Takuma
    Department of Otoralyngology,Head and Neck Surgery Okayama University hospital Head and Neck cancer centerOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Koyama Takahisa
    Department of Otoralyngology,Head and Neck Surgery Okayama University hospital Head and Neck cancer centerOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Ishihara Hisashi
    Department of Otoralyngology,Head and Neck Surgery Okayama University hospital Head and Neck cancer centerOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Hirai Haruka
    Department of Otoralyngology,Head and Neck Surgery Okayama University hospital Head and Neck cancer centerOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Haruna Takenori
    Department of Otoralyngology,Head and Neck Surgery Okayama University hospital Head and Neck cancer centerOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Kariya Shin
    Department of Otoralyngology,Head and Neck Surgery Okayama University hospital Head and Neck cancer centerOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Nishizaki Kazunori
    Department of Otoralyngology,Head and Neck Surgery Okayama University hospital Head and Neck cancer centerOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Bibliographic Information

Other Title
  • 重粒子線治療が有効であった顎下腺唾液腺導管癌 (salivary duct carcinoma) の1例

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Description

Salivary duct carcinoma (SDC) is an uncommon malignant tumor which accounts for only several percent in salivary gland cancer. It is the high grade malignancy which often causes local recurrence and lymph node and distant metastasis. Since the effect of radiotherapy and chemotherapy is small, surgical resection becomes the main treatment, and surgically unresectable cases have a poor prognosis. We report here that the heavy ion radiotherapy appears to be effective in the treatment of SDC in submandibular gland which was diagnosed as surgically unresectable.<br> The patient was a 55-year-old man with a left submandibular mass and a complete left facial sensory paralysis. In the MRI image, the tumors extended from submandibular gland to the skull base through lingual nerve. We thought that it was difficult to resect it completely. Instead, heavy ion radiotherapy was delivered to the unresectable upper site and bilateral neck dissection for cervical lymph node metastasis was performed subsequently. The metastases of lymph nodes were full of acidophil cells with HER2 protein positive and positive GCDFP-15, and we thus diagnosed it as SDC. Necrosis of most of the tumor tissue in the submandibular gland was observed. It implies that heavy ion radiotherapy is effective on SDC. It's been two years six months since the surgery, but there is not the sign of a recurrence.

Journal

  • Stomato-pharyngology

    Stomato-pharyngology 26 (2), 207-210, 2013

    Japan Society of Stomato-pharyngology

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