Inhibitory Potencies of Bromophenols from Rhodomelaceae Algae against α-Glucosidase Activity
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- Kurihara Hideyuki
- Department of Marine Bioresources Chemistry, Faculty of Fisheries, Hokkaido University
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- Mitani Takeshi
- Department of Marine Bioresources Chemistry, Faculty of Fisheries, Hokkaido University
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- Kawabata Jun
- Department of Bioscience and Chemistry. Faculty of Agriculture, Hokkaido University
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- Takahashi Koretaro
- Department of Marine Bioresources Chemistry, Faculty of Fisheries, Hokkaido University
書誌事項
- タイトル別名
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- Inhibitory Potencies of Bromophenols from Rhodomelaceae Algae against α-Glucosidase Activity
- Inhibitory Potencies of Bromophenols from Rhodomelaceae Algae against A-glucosidase Activity
- 公開日
- 1999
- 資源種別
- journal article
- DOI
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- 10.2331/fishsci.65.300
- 公開者
- 公益社団法人 日本水産学会
この論文をさがす
説明
Inhibitory potencies against α-glucosidase activities were compared among bromophenols obtained from extracts of three Rhodomelaceae red algae, Symphyocladia latiuscula, Odonthalia corymbifera, and Polysiphonia morrowii. The bromophenols from these species are characterized by a number of Br atoms per benzene ring: S. latiuscula, three Br atoms (1 and 2); O. corymbifera, two Br atoms (3-7); and P. morrowii, one Br atom (8 and 9). The bromophenols exhibited mixed inhibition against yeast α-glucosidase reaction. In particular, symmetric dibenzyl ethers, bis(2, 3, 6-tribromo-4, 5-dihydrox-ybenzyl) ether (2) and bis(2, 3-dibromo-4, 5-dihydroxybenzyl) ether (5), exhibited about 103 fold smaller Ki values than the other bromophenols. Their inhibition modes are disclosed to be mixed inhibition closed to competitive inhibition. Inhibitory potencies of the bromophenols increased with the increasing degree of bromo-substitution per benzene ring and the decreasing degree of methyl-substitution. In contrast to the strong inhibitory activity against yeast α-glucosidase activity, the bromophenols moderately inhibited rat-intestinal sucrase and maltase activity. The inhibitory potencies were all comparative among the bromophenols examined.
収録刊行物
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- Ｆｉｓｈｅｒｉｅｓ ｓｃｉｅｎｃｅ
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Ｆｉｓｈｅｒｉｅｓ ｓｃｉｅｎｃｅ 65 (2), 300-303, 1999
公益社団法人 日本水産学会
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詳細情報 詳細情報について
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- CRID
- 1390282679406444800
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- NII論文ID
- 130003903356
- 10004878523
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- NII書誌ID
- AA10993718
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- COI
- 1:CAS:528:DyaK1MXjt1SrsL8%3D
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- HANDLE
- 2115/48990
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- NDL書誌ID
- 4706598
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- ISSN
- 09199268
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- IRDB
- NDLサーチ
- Crossref
- CiNii Articles
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- 使用不可
