Development of Basic Technologies for Drop-Tower Experiments on Vertebrates

DOI Web Site 参考文献56件 オープンアクセス
  • Izumi Ryutaro
    Space Utilization Research Center, National Space Development Agency of Japan (NASDA), 2-1-1, Sengen, Tsukuba 305-8505 Japan Oarai Research and Development Center, Japan Atomic Energy Agency, 4002, Narita, Oarai 311-1393 Japan
  • Oishi Hirotaka
    Space Utilization Research Center, National Space Development Agency of Japan (NASDA), 2-1-1, Sengen, Tsukuba 305-8505 Japan Department of Social Medicine, Saga University Faculty of Medicine, 5-1-1, Nabeshima, Saga 849-8501 Japan
  • Higashibata Akira
    Space Utilization Research Center, National Space Development Agency of Japan (NASDA), 2-1-1, Sengen, Tsukuba 305-8505 Japan Department of Space Biology and Microgravity Sciences, and ISS Science Project Office, ISAS, Japan Aerospace Exploration Agency (JAXA), 2-1-1, Sengen, Tsukuba 305-8505 Japan
  • Yoshizaki Rika
    Space Utilization Research Center, National Space Development Agency of Japan (NASDA), 2-1-1, Sengen, Tsukuba 305-8505 Japan Toray Research Center, 3-1-8, Nihonbashi-Muromachi, Chuou-ku, Tokyo 103-0022 Japan
  • Ito Isao
    Space Utilization Research Center, National Space Development Agency of Japan (NASDA), 2-1-1, Sengen, Tsukuba 305-8505 Japan Space Environment Utilization Center, JAXA, 2-1-1, Sengen, Tsukuba 305-8505 Japan. Graduate School of Medicine and School of Medicine, Chiba University, 1-8-1, Inohana, Chuou-ku, Chiba, 260-8670 Japan
  • Murase Hirochika
    Space Utilization Research Center, National Space Development Agency of Japan (NASDA), 2-1-1, Sengen, Tsukuba 305-8505 Japan Kobe Shipyard and Machinery Works, Mitsubishi Heavy Industries Ltd., 1-1, Wadasaki-cho 1, Hyogo-ku, Kobe 652-8585 Japan
  • Inoue Makoto
    Faculty of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya 467-8603 Japan School of Pharmacy, Aichi Gakuin University, 1-100, Kusumoto-cho, Chikusa-ku, Nagoya 464-8650 Japan
  • Kato Katsunori
    Institute of Psychology, University of Tsukuba, Tsukuba 305-8572 Japan.
  • Kawashima Hitoshi
    Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba 305-8574 Japan Matsumoto Univ. Matsusho Junior College, 2095-1, Niimura, Matsumoto city, Nagano 390-1295 Japan
  • Soya Hideaki
    Institute of Health and Sports Sciences, University of Tsukuba, Tsukuba 305-8574 Japan
  • Ishioka Noriaki
    Space Utilization Research Center, National Space Development Agency of Japan (NASDA), 2-1-1, Sengen, Tsukuba 305-8505 Japan Department of Space Biology and Microgravity Sciences, and ISS Science Project Office, ISAS, Japan Aerospace Exploration Agency (JAXA), 2-1-1, Sengen, Tsukuba 305-8505 Japan

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説明

The purpose of this study is to evaluate several kinds of stress factors for small animals used with ground-based experiment facilities such as drop towers, parabolic flights, or centrifuges; and to mitigate the stressors, with the exception of gravity, in order to increase the scientific value of the experiment data and improve animal conditions. In the first step, we conducted experiments in a drop tower (Micro-Gravity Laboratory of Japan; MGLAB, Toki-city) and examined the following factors. 1) Environmental factors: Monitored and controlled environmental factors, such as temperature, humidity, oxygen and carbon dioxide concentration. 2) Evaluation of stress on animals: Biochemistry, in situ hybridization histochemistry, behavior, and physiology. From these results, we are able to estimate the degree of stress in drop-tower experiments to be level two on a scale of one to five level from the mildest state. The data and know-how we acquired will be summarized as a handbook and published for animal experiments employing the drop tower.

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