Bio-assessment of risk in long-term manned space exploration—Cell death factors in space radiation and/or microgravity: A review

DOI Web Site 被引用文献7件 参考文献134件 オープンアクセス
  • J. Majima Hideyuki
    Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan Space Environmental Medicine,Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan ISS Science Project Office, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Tsukuba, Ibaraki 305-8505, Japan
  • P. Indo Hiroko
    Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
  • Tomita Kazuo
    Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
  • Iwashita Yoichiro
    Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
  • Suzuki Hiromi
    Space Environmental Medicine,Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan Life Science Research Group, Department of Science and Applications, Japan Space Forum, Chiyoda, Tokyo100-0004, Japan
  • Masuda Daisuke
    Space Environmental Medicine,Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan Utilization & Engineering Department, Japan Manned Space Systems Corporation, Thuchiura, Ibaraki 300-0033, Japan
  • Shimazu Toru
    Life Science Research Group, Department of Science and Applications, Japan Space Forum, Chiyoda, Tokyo100-0004, Japan
  • Tanigaki Fumiaki
    Space Environment Utilization Center, Human Space System and Utilization Mission Directorate, Japan Aerospace Exploration Agency, Tsukuba, Ibaraki 305-8505, Japan
  • Umemura Sayaka
    Space Environment Utilization Center, Human Space System and Utilization Mission Directorate, Japan Aerospace Exploration Agency, Tsukuba, Ibaraki 305-8505, Japan
  • Yano Sachiko
    Space Environment Utilization Center, Human Space System and Utilization Mission Directorate, Japan Aerospace Exploration Agency, Tsukuba, Ibaraki 305-8505, Japan
  • Fukui Kei
    Life Science Research Group, Department of Science and Applications, Japan Space Forum, Chiyoda, Tokyo100-0004, Japan
  • Higashibata Akira
    Space Environmental Medicine,Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan Department of Space Biology and Microgravity Sciences, Japan Aerospace Exploration Agency, Tsukuba, Ibaraki 305-8505, Japan
  • Q Yamazaki Takashi
    ISS Science Project Office, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Tsukuba, Ibaraki 305-8505, Japan
  • Kameyama Masaki
    Physiology,Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
  • Suenaga Shigeaki
    Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
  • Sato Tsuyoshi
    Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
  • Yen Hsiu-Chuan
    Institute of Medical Technology, Chang Gung University, Tao-Yuan 333, Taiwan
  • Gusev Oleg
    Anhydrobiosis Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8575, Japan
  • Okuda Takashi
    Space Environmental Medicine,Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan Anhydrobiosis Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8575, Japan
  • Matsui Hirofumi
    Division of Gastroenterology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
  • Ozawa Toshihiko
    Department of Health Pharmacy, Yokohama College of Pharmacy, Totsuka 245-0066 Japan
  • Ishioka Noriaki
    Space Environmental Medicine,Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan Department of Space Biology and Microgravity Sciences, Japan Aerospace Exploration Agency, Tsukuba, Ibaraki 305-8505, Japan

書誌事項

タイトル別名
  • Bio-Assessment of RISK in Long-Term Manned Space Exploration-Cell Death Factors in Space Radiation and/or Microgravity: A Review-

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説明

One major concern regarding long-term manned space missions is the effect of accumulative doses of space radiation (the mean daily dose is 0.2 ∼ 1 mSv). Such missions will inevitably expose astronauts to significant doses, and thus are expected to increase the risks of radiation-related carcinogenicity, neurotoxicity, and lifespan changes. These effects occur by nuclear and cytosol dysfunction, mitochondrial damage, and particular changes in signal transduction or protein synthesis. In addition, microgravity may affect cellular metabolisms, signal transduction, etc., and might lead to synergistic effects with space radiation, which could result in further risk. Because these effects will almost certainly involve cellular signaling, transcriptomics and proteomics will be powerful tools in their analysis. In order to suitably respond to all these risks, both protective measures based on physical and biological principles, and effective intra-flight assessment of the levels of radiation exposure will be required. In this article, the categories of cell death-i.e., apoptosis, necrosis and autophagy-and the recent studies on these mechanisms are reviewed.

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