Effects of Docosahexaenoic Acid on the Endothelial Function in Patients with Coronary Artery Disease

  • Yagi Shusuke
    Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
  • Aihara Ken-ichi
    Department of Medicine and Bioregulatory Sciences, the University of Tokushima Graduate School of Health Biosciences
  • Fukuda Daiju
    Department of Cardio-Diabetes Medicine, the University of Tokushima Graduate School of Health Biosciences
  • Takashima Akira
    Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
  • Hara Tomoya
    Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
  • Hotchi Junko
    Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
  • Ise Takayuki
    Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
  • Yamaguchi Koji
    Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
  • Tobiume Takeshi
    Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
  • Iwase Takashi
    Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
  • Yamada Hirotsugu
    Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
  • Soeki Takeshi
    Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
  • Wakatsuki Tetsuzo
    Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences
  • Shimabukuro Michio
    Department of Cardio-Diabetes Medicine, the University of Tokushima Graduate School of Health Biosciences
  • Akaike Masashi
    Department of Medical Education, the University of Tokushima Graduate School of Health Biosciences
  • Sata Masataka
    Department of Cardiovascular Medicine, the University of Tokushima Graduate School of Health Biosciences

この論文をさがす

説明

Aim: The consumption of n-3 polyunsaturated fatty acids (PUFA), including docosahexaenoic acid DHA), reduces the incidence of cardiovascular events, and reduced serum levels of n-3 PUFA may be associated with an increased risk of cardiovascular events. However, controversy remains regarding which components of PUFA are associated with the endothelial function in patients with coronary artery disease (CAD). We therefore examined the associations between the n-3 and n-6 PUFA levels and CAD.<br>Methods: We retrospectively reviewed 160 consecutive Japanese patients with CAD whose endothelial function was measured according to the percent change in flow-mediated dilation (FMD) and the serum levels of n-3 PUFA, including eicosapentaenoic acid (EPA) and DHA, and n-6 PUFA, including arachidonic acid (AA) and dihomo-gamma-linolenic acid (DHLA).<br>Results: A single regression analysis showed no relationships between the FMD and the serum levels of PUFA, including EPA, DHA, AA and DHLA. In contrast, a multiple regression analysis showed that the DHA level was a positive (P<0.01) and age was a negative (P<0.001) contributor to an increased FMD; however, sex, body mass index, systolic and diastolic blood pressure, current/past smoking and the levels of HbA1c, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, EPA, AA and DHLA did not significantly affect the outcome.<br>Conclusions: The serum level of DHA is associated with the endothelial function evaluated according to the FMD in patients with CAD, thus suggesting that a low serum level of DHA may be a predictive biomarker for endothelial dysfunction.

収録刊行物

被引用文献 (11)*注記

もっと見る

参考文献 (28)*注記

もっと見る

関連プロジェクト

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ