High-Density Lipoprotein Subfractions and Their Oxidized Subfraction Particles in Patients with Chronic Kidney Disease
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- Honda Hirokazu
- Division of Nephrology, Department of Medicine, Showa University Koto Toyosu Hospital
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- Hirano Tsutomu
- Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Showa University School of Medicine
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- Ueda Masashi
- Ikagaku Co. Ltd.
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- Kojima Shiho
- Ikagaku Co. Ltd.
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- Mashiba Shinichi
- Ikagaku Co. Ltd.
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- Hayase Yasuyuki
- Ikagaku Co. Ltd.
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- Michihata Tetsuo
- Ebara Clinic
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- Shibata Takanori
- Division of Nephrology, Department of Medicine, Showa University School of Medicine
書誌事項
- 公開日
- 2016
- 資源種別
- journal article
- DOI
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- 10.5551/jat.30015
- 公開者
- 一般社団法人 日本動脈硬化学会
この論文をさがす
説明
Aim: Chronic kidney disease (CKD) may lead to reduced concentrations of high-density lipoprotein (HDL) and its subfractions (HDL2 and HDL3), and damage them via inflammation and oxidative stress. The present study aimed to determine the contribution of such changes to cardiovascular disease (CVD) in patients with CKD.<br>Methods: The levels of total cholesterol, low-density lipoprotein cholesterol, HDL-C, HDL2, HDL3, apolipoproteins, malondialdehyde-modified LDL (MDA-LDL), oxidized (ox) HDL, oxHDL2, and oxHDL3 were measured in blood samples from patients with CKD (stages 2–5, n=86) who were not on dialysis and from patients undergoing hemodialysis (CKD stage 5D, n=25). The patients were followed up for 28±9 months after baseline examinations and CVD events were recorded.<br>Result: The levels of HDL3 and ApoA1 in HDL3 fraction decreased according to CKD severity, whereas those of HDL2 and ApoA1 in HDL2 fraction did not differ. The levels of oxHDL were similar across CKD stages. The levels of oxHDL3 and MDA-LDL were decreased, whereas those of oxHDL2 increased according to CKD severity. Multivariate analyses using the Cox proportional hazards model selected high levels of oxHDL and its subfractions, and those adjusted with HDL-C and HDL subfractions or ApoA1 in HDL fractions respectively, compared with HDL-C and HDL subfractions or ApoA1 in HDL fractions alone as independent risk factors for CVD events.<br>Conclusion: The levels of HDL subfractions and their oxidized subfraction particles differed among patients with CKD. The increasing levels of oxHDL subfractions might cause a high frequency of CVD events in such patients.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 23 (1), 81-94, 2016
一般社団法人 日本動脈硬化学会