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- Pal Shripad Nagesh
- Vascular Biology Unit, Department of Surgery, School of Medicine and Dentistry, James Cook University.
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- Golledge Jonathan
- Vascular Biology Unit, Department of Surgery, School of Medicine and Dentistry, James Cook University.
書誌事項
- タイトル別名
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- —A Circulating Cell Theory
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説明
Vascular calcification has been associated with the incidence of cardiovascular events and thus there has been interest in better understanding its pathogenesis. Early theories considered vascular calcification to be a passive process which occurred as a non-specific response to tissue injury or necrosis. More recent theories propose vascular calcification results from loss of molecular inhibitors or via an active cell mediated process. The origin of the cells responsible for vascular calcification is controversial and may vary in different sites and patients. Calcification has been reported as result of apoptosis or death of vascular smooth muscle cells for example. One novel source of cells controlling vascular calcification is from the bone marrow. A circulating immature bone marrow derived population has been identified and a small subset of this bone marrow population has been reported to possess bone forming properties in vitro and hence termed osteo-progenitors. This article reviews evidence supporting the contribution of these naive bone marrow derived circulating osteo-progenitor cells in vascular calcification.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 18 (7), 551-559, 2010
一般社団法人 日本動脈硬化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679408573696
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- NII論文ID
- 130004444521
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- DOI
- 10.5551/jat.8656
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- ISSN
- 18803873
- 13403478
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 使用不可