The Multiple Roles of Macrophage Scavenger Receptors (MSR) in vivo : Resistance to Atherosclerosis and Susceptibility to Infection in MSR Knockout Mice
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- Suzuki Hiroshi
- Exploratory Research Laboratory, Chugai Pharmaceutical Co. Ltd.
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- Kurihara Yukiko
- The Third Department of Internal Medicine, University of Tokyo
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- Takeya Motohiro
- The Second Department of Pathology, Kumamoto University School of Medicine
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- Kamada Nobuo
- Exploratory Research Laboratory, Chugai Pharmaceutical Co. Ltd.
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- Kataoka Motoyuki
- Exploratory Research Laboratory, Chugai Pharmaceutical Co. Ltd.
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- Jishage Kouichi
- Exploratory Research Laboratory, Chugai Pharmaceutical Co. Ltd.
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- Sakaguchi Hisashi
- The Second Department of Pathology, Kumamoto University School of Medicine
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- Kruijt J. Kar
- Division of Biopharmaceutics, Leiden University
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- Higashi Takayuki
- The Department of Biochemistry, Kumamoto University School of Medicine
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- Suzuki Tsukasa
- Exploratory Research Laboratory, Chugai Pharmaceutical Co. Ltd.
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- Berkel Theo J.C.van
- Division of Biopharmaceutics, Leiden University
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- Horiuchi Seikoh
- The Department of Biochemistry, Kumamoto University School of Medicine
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- Takahashi Kiyoshi
- The Second Department of Pathology, Kumamoto University School of Medicine
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- Yazaki Yoshio
- The Third Department of Internal Medicine, University of Tokyo
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- Kodama Tatsuhiko
- Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo
書誌事項
- タイトル別名
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- The Multiple Roles of Macrophage Scavenger Receptors (MSR) <I>in vivo</I> : Resistance to Atherosclerosis and Susceptibility to Infection in MSR Knockout Mice
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説明
Both type I and type II MSRs are integral membrane proteins containing a collagenous domain and elicit an extraordinarily wide range of ligand binding capability. They were found during the search for the molecule (s) responsible for the accumulation of modified LDL during atherogenesis. However, all prior the evidence relating to their physiological and pathophysiological roles in vivo had been indirect. Targeted disruption of the MSR gene results in a reduction in the size of atherosclerotic lesions in an apo E deficient animal. Macrophages from MSR deficient mice exhibit a marked decrease in modified LDL uptake in vitro, whereas modified LDL clearance from plasma remains normal, suggesting that there are alternative mechanisms for the uptake of modified LDL from the circulation. In addition, MSR knockout mice are more susceptible to L. monocytogenes and HSV-1 infection, indicating a role for MSR in host defense against various pathogens. J Atheroscler Thromb, 1997 ; 4 : 1-11.
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ
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Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ 4 (1), 1-11, 1997
一般社団法人 日本動脈硬化学会