Effects of Supervised Aerobic Exercise Training on Serum Adiponectin and Parameters of Lipid and Glucose Metabolism in Subjects with Moderate Dyslipidemia

DOI PubMed 13 Citations 33 References Open Access
  • Yoshida Hiroshi
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital. Department of Laboratory Medicine, Jikei University School of Medicine. Internal Medicine of Metabolism and Nutrition, Jikei University Graduate School of Medicine.
  • Ishikawa Toshitsugu
    Wellness Center, SONY Corp. Department of Nutrition and Life Science, Faculty of Applied Bioscience, Kanagawa Institute of Technology.
  • Suto Michiko
    Wellness Center, SONY Corp.
  • Kurosawa Hideo
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital.
  • Hirowatari Yuji
    Bioscience Division, TOSOH Corp.
  • Ito Kumie
    Internal Medicine of Metabolism and Nutrition, Jikei University Graduate School of Medicine.
  • Yanai Hidekatsu
    Internal Medicine of Metabolism and Nutrition, Jikei University Graduate School of Medicine. Department of Internal Medicine, Kohnodai Hospital, National Center for Global Health and Medicine.
  • Tada Norio
    Internal Medicine of Metabolism and Nutrition, Jikei University Graduate School of Medicine.
  • Suzuki Masato
    Department of Laboratory Medicine, Jikei University School of Medicine.

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Aim: To examine the effects of supervised aerobic exercise training on serum adiponectin and lipids, including triglyceride (TG)-rich lipoproteins, in moderate dyslipidemic subjects.<BR>Methods: Twenty-five dyslipidemic patients [mean body mass index (BMI)=24.6 kg/m2; mean age= 39 years; mean total cholesterol=226 mg/dL; mean TG=149 mg/dL] without metabolic syndrome, diabetes, and hypertension underwent supervised aerobic exercise training (60 min/day, 2 to 3 times/week) at an intensity of 60-80% of age-predicted maximal heart rate for 16 weeks. Lipoprotein cho-lesterol levels were measured by our established anion-exchange HPLC method.<BR>Results: Aerobic exercise training significantly decreased BMI, cholesterol levels of LDL- and IDL-, and markedly reduced VLDL-cholesterol at week 8 (-45%) and week 16 (-50%), but changes in TG and HDL-cholesterol were not significant. Adiponectin significantly increased by 51% and HOMA-R was significantly decreased at week 16, although changes in these parameters were not sig-nificant at week 8. There was no significant relationship between changes in adiponectin and in VLDL- or IDL- cholesterol, but changes in adiponectin were inversely but insignificantly associated with changes in BMI (r=-0.343, p=0.095).<BR>Conclusions: These results suggest that supervised aerobic exercise training two to three times/week in the presence of body weight loss increases serum adiponectin with an improved lipid profile and insulin sensitivity at week 16 in non-obese moderate dyslipidemic patients, and that VLDL-choles-terol is markedly decreased by supervised aerobic exercise training.

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Details 詳細情報について

  • CRID
    1390282679410075520
  • NII Article ID
    130004444382
    50007832108
  • DOI
    10.5551/jat.4358
  • COI
    1:STN:280:DC%2BC3M%2FhtV2hsw%3D%3D
  • ISSN
    18803873
    13403478
  • PubMed
    20805637
  • Web Site
    https://search.jamas.or.jp/link/ui/2011240255
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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