Depot-Specific Expression of Lipolytic Genes in Human Adipose Tissues

DOI PubMed 3 Citations 47 References Open Access
  • Nagashima Shuichi
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
  • Yagyu Hiroaki
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
  • Takahashi Nirei
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
  • Kurashina Tomoyuki
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
  • Takahashi Manabu
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
  • Tsuchita Takeshi
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
  • Tazoe Fumiko
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
  • Wang Xiao Li
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
  • Bayasgalan Tumenbayar
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
  • Sato Naoko
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
  • Okada Kenta
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
  • Nagasaka Shoichiro
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.
  • Gotoh Takaya
    Division of Human Genetics, Center for Community Medicine, Jichi Medical University.
  • Kojima Masayuki
    Department of Surgery, Jichi Medical University.
  • Hyodo Masanobu
    Department of Surgery, Jichi Medical University.
  • Horie Hisanaga
    Department of Surgery, Jichi Medical University.
  • Hosoya Yoshinori
    Department of Surgery, Jichi Medical University.
  • Okada Masaki
    Department of Surgery, Jichi Medical University.
  • Yasuda Yoshikazu
    Department of Surgery, Jichi Medical University.
  • Fujiwara Hiroyuki
    Department of Obstetrics and Gynecology, Jichi Medical University.
  • Ohwada Michitaka
    Department of Obstetrics and Gynecology, Jichi Medical University.
  • Iwamoto Sadahiko
    Division of Human Genetics, Center for Community Medicine, Jichi Medical University.
  • Suzuki Mitsuaki
    Department of Obstetrics and Gynecology, Jichi Medical University.
  • Nagai Hideo
    Department of Surgery, Jichi Medical University. Department of Surgery, Ibaraki Prefectural Central Hospital.
  • Ishibashi Shun
    Division of Endocrinology and Metabolism, Diabetes Center, Department of Medicine, Jichi Medical University.

Bibliographic Information

Other Title
  • Depot-specific expression of lipolytic genes in human adipose tissues—association among CES1 expression, triglyceride lipase activity and adiposity
  • Depot-specific expression of lipolytic genes in human adipose tissues--association among CES1 expression, triglyceride lipase activity and adiposity
  • —Association Among <i>CES1</i> Expression, Triglyceride Lipase Activity and Adiposity

Search this article

Description

Aim: Adipocyte lipolysis is mediated by a family of triglyceride (TG) lipases consisting of hormone-sensitive lipase (LIPE), adipose triglyceride lipase (PNPLA2) and carboxylesterase 1 (CES1); however, little is known about the relationship between the expression of each gene in different depots and TG lipase activity or obesity.<BR>Method: We measured both mRNA expression levels of the lipolytic enzymes (LIPE, PNPLA2 and CES1) and TG lipase activities of biopsy samples obtained from subcutaneous, omental and mesenteric adipose tissues of 34 patients who underwent abdominal surgery. The results were correlated with clinical parameters: adiposity measures, parameters for insulin resistance and plasma lipid levels.<BR>Results: PNPLA2 mRNA levels were slightly higher in omental fat than subcutaneous fat. Cytosolic TG lipase activities were positively correlated with the mRNA levels of CES1 in subcutaneous fat and mesenteric fat, while they were correlated with those of PNPLA2 in omental fat. The mRNA levels of LIPE were negatively correlated with various measures of adiposity in subcutaneous fat. The mRNA levels of CES1 were positively correlated with various measures of adiposity, particularly those estimated by CT in the three depots; they were also positively correlated with plasma LDL-cholesterol levels in omental fat. In contrast, the mRNA levels of PNPLA2 were not significantly associated with adiposity.<BR>Conclusions: The positive correlations of the expression of CES1 with cytosolic TG lipase activities as well as with adiposity suggest that CES1 is involved in lipolysis, thereby contributing to the development of obesity-associated phenotypes. On the other hand, the expression of LIPE is negatively correlated with adiposity. These distinct regulatory patterns of lipolytic genes may underlie the complex phenotypes associated with human obesity.

Journal

Citations (3)*help

See more

References(47)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

  • CRID
    1390282679410094848
  • NII Article ID
    130004444498
  • DOI
    10.5551/jat.6478
  • ISSN
    18803873
    13403478
  • PubMed
    21081832
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
    • KAKEN
    • OpenAIRE
  • Abstract License Flag
    Disallowed

Report a problem

Back to top