Inference of causal effects between pregnant women's sensitivity to cold (hiesho) and premature rupture of membranes

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  • 妊婦の冷え症と前期破水における因果効果の推定
  • —Adjustment of confounding factors by propensity scores—
  • —傾向スコアによる交絡因子の調整—

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Purpose<br> The purpose of this study is to carry out a comparative analysis of Japanese women with and without sensitivity to cold (hiesho) during pregnancy with regard to incidence of premature rupture of membranes and infer the causal effects as to whether sensitivity to cold (hiesho) induces premature rupture of membranes.<br>Method<br> The study design was a retrospective cohort study. Data was collected for approximately twelve months between October 19, 2009 and October 8, 2010 at six general hospitals with obstetric and pediatric departments in the Greater Tokyo Metropolitan Area. The study was conducted on 2,810 postpartum Japanese women inpatients at those hospitals, and their information was extracted from questionnaire surveys and medical records. In this analysis, confounding factors were adjusted using propensity scores.<br>Results<br> Out of 662 women (23.6%) with premature rupture of membranes, 348 (52.6%) had sensitivity to cold (hiesho) and 314 (47.4%) did not. Incidence of premature rupture of membranes is 1.67 times higher (analysis of covariance) or 1.69 times higher (stratified analysis) among pregnant women with sensitivity to cold (hiesho) than those without sensitivity to cold (hiesho) (p<.001).<br>Conclusions<br> It was strongly inferred that causal effects exist between sensitivity to cold (hiesho) and premature rupture of membranes.

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