Genetic approach for low back pain

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  • 遺伝子学的手法を用いた腰痛へのアプローチ
  • イデンシガクテキ シュホウ オ モチイタ ヨウツウ エノ アプローチ

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Abstract

The cause of low back pain is multi-factorial. It has been suggested that lumbar disc disease (LDD) is one of the cause of low back pain. Recently, many data suggests that genetic background contributes to lumbar disc disease. In our previous study, we showed that a functional single nucleotide polymorphism (SNP) (1184T→C) in CILP (cartilage intermediate layer protein) acts as a modulator of LDD susceptibility. We also indicated the mechanism how the susceptibility gene in CLIP cause LDD. Through the genetic approach, the cause of low back pain has been elucidated. In this manuscript, we have reviewed the genetic approach for low back pain.

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