A case of metformin-associated lactic acidosis followed by Takotsubo cardiomyopathy
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- Jin Joo Woo
- Department of Emergency and Intensive Care Medicine, Otsu Municipal Hospital
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- Koogichi Kunihiko
- Department of Emergency and Intensive Care Medicine, Otsu Municipal Hospital
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- Fukui Michihiko
- Department of Emergency and Intensive Care Medicine, Otsu Municipal Hospital
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- Shinzato Taiichi
- Department of Emergency and Intensive Care Medicine, Otsu Municipal Hospital
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- Sakaguchi Masahiro
- Department of Emergency and Intensive Care Medicine, Otsu Municipal Hospital
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- Itagaki Naruhiko
- Department of Emergency and Intensive Care Medicine, Otsu Municipal Hospital
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- Inami Naoko
- Department of Emergency and Intensive Care Medicine, Otsu Municipal Hospital
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- Fujiwara Daisuke
- Department of Emergency and Intensive Care Medicine, Otsu Municipal Hospital
Bibliographic Information
- Other Title
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- メトホルミンによる乳酸アシドーシスにたこつぼ心筋症を続発した1症例
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Description
We report a case of a 66-year-old woman who had metformin-associated lactic acidosis after overdosing of zolpidem tartrate. She displayed restlessness on admission to our emergency room. Blood gas analysis showed severe lactic acidosis and she was admitted to the ICU. After 9 hours, she complained of chest pain. Apical ballooning was observed on echocardiography, and Takotsubo cardiomyopathy was suspected. Her condition resolved, and on the 9th hospital day, she was discharged from the ICU. Lactic acidosis is a rare but sometimes fatal adverse effect of metformin. In this case, respiratory failure as a result of zolpidem tartrate overdose may have induced severe lactic acidosis, which is associated with metformin. The physical stress of lactic acidosis and the psychic stress which caused suicide attempt might eventually result in Takotsubo cardiomyopathy.
Journal
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- Journal of the Japanese Society of Intensive Care Medicine
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Journal of the Japanese Society of Intensive Care Medicine 20 (1), 47-50, 2013
The Japanese Society of Intensive Care Medicine
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Details 詳細情報について
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- CRID
- 1390282679421026048
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- NII Article ID
- 130004514486
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- ISSN
- 1882966X
- 13407988
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed