Plasma exchange and the prognosis of renal dysfunction in three pediatric patients with hemolytic uremic syndrome

  • Yanagi Akio
    Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine
  • Hara Yoshitaka
    Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine
  • Uchiyama Sohta
    Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine
  • Maeda Takayasu
    Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine
  • Komatsu Satoshi
    Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine
  • Hayakawa Seiko
    Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine
  • Shibata Junpei
    Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine
  • Nishida Osamu
    Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine

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Other Title
  • 小児溶血性尿毒症症候群の3例:血漿交換療法の有無による検討

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Abstract

The usefulness of plasma exchange (PE) for hemolytic uremic syndrome (HUS) by enterohemorrhagic Escherichia coli (EHEC) is unclear. On the other hand, there were no reports of the relationship between central nervous system (CNS) disorder and renal dysfunction. We report three pediatric patients with HUS by EHEC, two patients with PE and one without PE, and their renal dysfunction. The subjects were 3 patients with HUS by EHEC admitted to the ICU. On admission, anuria was noted in all subjects. Continuous hemodiafiltration (CHDF) was started. In 2 patients with CNS disorder, PE was performed for 3 days starting from 9 and 10 days after the onset of digestive symptoms, respectively. In these patients, CNS disorder was not observed on discharge from the ICU. The CHDF period was 9 and 13 days, respectively. It was 36 days in a non-PE-treated patient without CNS disorder.

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