Factors related to quality of life in patients with hemophilia

DOI 1 Citations 9 References
  • GOTO Miwa
    Rehabilitation Center, The University of Tokyo Hospital Department of Physical Therapy, Graduate School of Human Health Sciences, Tokyo Metropolitan University
  • TAKEDANI Hideyuki
    Department of Joint Surgery, Research Hospital of The Institute of Medical Science, The University of Tokyo
  • KAWAMA Kennosuke
    Graduate School of Comprehensive Human Sciences, Tsukuba University
  • NITTA Osamu
    Department of Physical Therapy, Graduate School of Human Health Sciences, Tokyo Metropolitan University

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  • 血友病患者における健康関連QOL に影響を与える要因

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There are many factors which affect hemophilic patients’ quality of life (QOL), intra-articular bleeding, inhibitor, infection caused by transfusions using unheated blood products, arthropathy, and disability, but which of these has the biggest effect is not yet clear. This study aims to find a determinant of health-related QOL (HRQOL) in hemophilia. Questionnaire survey was conducted in hemophilic patients over the age of 16. The main points investigated were the subjects’ biographical data, such as age, coagulation factor levels, employment, levels of satisfaction regarding physical and mental support, activities of daily living (ADL), and HRQOL using The RAND 36-item Health Survey 2.0 Japanese version. There were 259 (37.5%) valid responses, average age was 40.9 years old. 64.5% of patients ware severe of hemophilia. 78.8% of the patients were HCV-positive, 35.5% were HIV-positive, 8.9% were Inhibitor-positive. Results of binary step-wise logistic regression analysis show that determinant of physical aspects of HRQOL was ADL, determinant of mental aspects of HRQOL was satisfaction regarding support from work places. Comprehensive intervention is necessary to improvement of ADL and vocational assistance in order to improve the hemophilia patient’s HRQOL.

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