A Method for Routine Analysis of Urinary 4,4'-methylenebis (2-chloroaniline) by Gas Chromatography-Electron Capture Detection
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- Takeuchi Akito
- Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association
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- Namera Akira
- Department of Forensic Medicine, Institute of Biomedical and Health Sciences, Hiroshima University
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- Sakui Norihiro
- Agilent Technologies
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- Yamamuro Kenji
- Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association
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- Kawai Toshio
- Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association
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- Sumino Kimiaki
- Osaka Occupational Health Service Center, Japan Industrial Safety and Health Association
書誌事項
- タイトル別名
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- A Method for Routine Analysis of Urinary 4,4′-methylenebis (2-chloroaniline) by Gas Chromatography-Electron Capture Detection
- A Method for Routine Analysis of Urinary 4,4′‐methylenebis (2‐chloroaniline) by Gas Chromatography‐Electron Capture Detection
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説明
Objectives: The purpose of this study was to develop a simple and cost-effective method for the determination of urinary 4,4′-methylenebis (2-chloroaniline) (MBOCA) by gas chromatography-electron capture detection (GC-ECD) for biological monitoring of occupational exposure to MBOCA. Methods: MBOCA was prepared by liquid-liquid extraction after alkaline hydrolysis, derivatized with N-methyl-bis (trifluoroacetamide) and then analyzed using GC-ECD. The proposed method was validated in accordance with the US Food and Drug Administration guidance. Results: The calibration curve showed linearity in the range 1–100 µg/l, with a correlation coefficient of >0.999. The limits of detection and quantification were 0.3 µg/l and 1 µg/l, respectively. The recovery was 94–99%. Intraday accuracy, expressed as the deviation from the nominal value, was 90.5–100.3%, and intraday precision, expressed as the relative standard deviation, was 0.3–2.4%. Interday accuracy and precision were 87.8–100.2% and 0.3–4.1%, respectively. Conclusions: The proposed method is a simple and cost-effective method suitable for routine analyses and could be useful for biological monitoring of occupational exposure to MBOCA.(J Occup Health 2014; 56: 347-350)
収録刊行物
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- journal of Occupational Health
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journal of Occupational Health 56 (5), 347-350, 2014
公益社団法人 日本産業衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390282679430696064
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- NII論文ID
- 130004704500
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- NII書誌ID
- AA11090645
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- ISSN
- 13489585
- 13419145
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- NDL書誌ID
- 025824017
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- PubMed
- 25069897
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可