Urinary Mutagenicity, CYP1A2 and NAT2 Activity in Textile Industry Workers
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- Fanlo Ana
- Department of Pharmacology and Physiology, University of Zaragoza
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- Sinuès Blanca
- Department of Pharmacology and Physiology, University of Zaragoza
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- Mayayo Esteban
- Department of Pharmacology and Physiology, University of Zaragoza
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- Bernal Luisa
- Department of Pharmacology and Physiology, University of Zaragoza
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- Soriano Antonia
- Department of Pharmacology and Physiology, University of Zaragoza
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- Martínez-Jarreta Begoña
- Department of Occupational Health, University of Zaragoza
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- Martínez-Ballarín Enrique
- Department of Pharmacology and Physiology, University of Zaragoza
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説明
The two major causes of bladder cancer have been recognised to be cigarette smoke and occupational exposure to arylamines. These compounds are present both in tobacco smoke and in the dyes used in textile production. Aromatic amines suffer oxidative metabolism via P450 cytochrome CYP1A2, and detoxification by the polymorphic NAT2. The aim of the present work was to assess the association between occupational-derived exposure to mutagens and CYP1A2 or NAT2 activity. This cross-sectional study included 117 textile workers exposed to dyes and 117 healthy controls. The urinary mutagenicity was determined in 24 h urine using TA98 Salmonella typhimurium strain with microsomal activation S9 (MIS9) or incubation with β-glucuronidase (MIβ). Urinary caffeine metabolite ratios: AFMU+1X+1U/17U, and AFMU/AFMU+1X+1U were calculated to assess CYP1A2 and NAT2 activities, respectively. The results show that workers present a strikingly higher urine mutagenicity than controls (p<0.0001), despite the implementation of the new restrictive norms forbidding the industrial use of the most carcinogenic arylamines. Neither NAT2 nor CYP1A2 activity had any effect on the markers of internal exposure to mutagens, since no significant differences were observed when the urinary mutagenicity of slow and fast acetylators (p>0.05) was compared, and the urinary mutagenicity was not significantly associated with the CYP1A2 activity marker (r=0.04 and r=-0.01 for MIS9 and MIβ, respectively). This study clearly indicates the need for further protective policies to minimise exposure to the lowest feasible limit in order to avoid unnecessary risks.<br>
収録刊行物
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- journal of Occupational Health
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journal of Occupational Health 46 (6), 440-447, 2004
公益社団法人 日本産業衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390282679430747904
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- NII論文ID
- 130004447238
- 110003723230
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- NII書誌ID
- AA11090645
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- ISSN
- 13489585
- 13419145
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- NDL書誌ID
- 7177541
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- PubMed
- 15613766
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可