Oral Toxicity of Bismuth in Rat: Single and 28-Day Repeated Administration Studies
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- Sano Yuri
- Department of Preventative Medicine and Public Health, School of Medicine, Keio University
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- Satoh Hiroshi
- Environmental Health Sciences, Tohoku University Graduate School of Medicine
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- Chiba Momoko
- Department of Epidemiology and Environmental Health, Juntendo University School of Medicine
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- Okamoto Masahide
- Hitachi Ltd., Production Engineering Research Laboratory
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- Serizawa Koji
- Hitachi Ltd., Production Engineering Research Laboratory
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- Nakashima Hiroshi
- Department of Preventative Medicine and Public Health, School of Medicine, Keio University
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- Omae Kazuyuki
- Department of Preventative Medicine and Public Health, School of Medicine, Keio University
Bibliographic Information
- Other Title
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- Oral Toxicity of Bismuth in Rat: Single and 28‐Day Repeated Administration Studies
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Abstract
The consumption and production of bismuth are increasing, however there is very little information about the direct toxic effect of bismuth. The present study aimed to characterize the potential toxic effects of bismuth through oral administration and observation for fourteen days following single dose of 0 and 2,000 mg/kg (acute oral toxicity study), and repeated oral administration for twenty-eight days at dose levels of 0, 40, 200, and 1,000 mg/kg daily (28-d repeated oral dose toxicity study) to male and female Crj:CD (SD) IGS rats (SPF). We found no deaths and no abnormalities in clinical signs, body weights, and necropsy findings for any of the animals in the acute oral toxicity study and no changes attributable to bismuth in either males or females in the dose group up to 1,000 mg/kg of the 28-d repeated-dose toxicity study. Therefore, we determined that the lethal dose with a 50% mortality rate (LD50) is greater than 2,000 mg/kg and the no-observed-adverse-effect level (NOAEL) of bismuth is 1,000 mg/kg in both sexes. We conclude that the adverse toxic effects of bismuth as a simple metal substance are low compared to lead toxicity under the conditions tested in our studies.<br>
Journal
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- Journal of Occupational Health
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Journal of Occupational Health 47 (4), 293-298, 2005
Japan Society for Occupational Health
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Keywords
Details 詳細情報について
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- CRID
- 1390282679431237504
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- NII Article ID
- 130004447286
- 10016670991
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- NII Book ID
- AA11090645
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- COI
- 1:CAS:528:DC%2BD2MXpvVCrtr4%3D
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- ISSN
- 13489585
- 13419145
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- NDL BIB ID
- 7378803
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- PubMed
- 16096353
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed