The Prophylactic and Therapeutic Effects of Cholinolytics on Perfluoroisobutylene Inhalation Induced Acute Lung Injury
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- Zhang Tianhong
- Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
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- Zhang Xigang
- 307 Hospital
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- Shao Zhihua
- Quhua Hospital, Quhua Group Corporation
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- Ding Rigao
- Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
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- Yang Shunjiang
- Quhua Hospital, Quhua Group Corporation
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- Ruan Jinxiu
- Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
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- Sun Xiaohong
- Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
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- Xu Jin
- Quhua Hospital, Quhua Group Corporation
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- Huang Chunqian
- Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
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- Hu Zuliang
- Quhua Hospital, Quhua Group Corporation
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- Zhang Xianchang
- Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
書誌事項
- タイトル別名
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- Prophylactic and Therapeutic Effects of Cholinolytics on Perfluoroisobutylene Inhalation Induced Acute Lung Injury
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抄録
Perfluoroisobutylene (PFIB) is a kind of fluoro-olefin that is ten times more toxic than phosgene. The mechanisms of the acute lung injury (ALI) induced by PFIB inhalation remain unclear. To find possible pharmacological interventions, mice and rats were exposed to PFIB, and the prophylactic or therapeutic effects of 3-quinuclidinyl benzilate (QNB) and anisodamine were studied and confirmed. It was observed that the wet lung/body weight and the dry lung/body weight ratios at 24 h after PFIB exposure (130 mg/m3 for 5 min) were significantly decreased when a single dose of QNB (5 mg/kg) was administered intraperitoneally either 30 min before exposure or 10 h after exposure. Anisodamine was without any prophylactic or therapeutic effects at single doses below 30 mg/kg. The effects of QNB against PFIB inhalation induced ALI were well evidenced by the significantly decreased mice mortality at 72 h, the total protein concentration in bronchoalveolar lavage fluid at 24 h after the PFIB exposure, as well as the ultrastructural observations. The analysis of the time courses of lung sulfhydryl concentration, myeloperoxidase (MPO) activity and hemorheology assay showed that the toxicity of PFIB may be due to consumption of lung protein sulfhydryl, influx of polymorphonuclear leukocytes (PMNs) into the lung, and increased peripheral blood viscosity at a low shear rate, all of which were partially blocked by QNB intervention except for PMN influx. The results suggest that cholinolytics might have prophylactic and therapeutic roles in PFIB inhalation induced ALI.<br>
収録刊行物
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- journal of Occupational Health
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journal of Occupational Health 47 (4), 277-285, 2005
公益社団法人 日本産業衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390282679431241216
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- NII論文ID
- 130004447284
- 10016670916
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- NII書誌ID
- AA11090645
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- COI
- 1:CAS:528:DC%2BD2MXpvVCrsbY%3D
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- ISSN
- 13489585
- 13419145
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- NDL書誌ID
- 7378781
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- PubMed
- 16096351
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可