The Effects of Allyl Chloride on Ca<sup>2+</sup>, Ca<sup>2+</sup>‐Free CaM, cAMP and Ca<sup>2+</sup>/CaM‐PK II Activity in Nerve Cells

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  • XIE Keqin
    Institute of Toxicology, Shandong Medical University
  • GAO Shujun
    Institute of Toxicology, Shandong Medical University
  • ZHANG Lei
    Institute of Toxicology, Shandong Medical University
  • ZHANG Min
    Institute of Toxicology, Shandong Medical University
  • SUN Keren
    Institute of Toxicology, Shandong Medical University

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  • The Effects of Allyl Chloride on Ca2+, Ca2+-Free CaM, cAMP and Ca2+/CaM-PK II Activity in Nerve Cells.

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The Effects of Allyl Chloride on Ca2+, Ca2+ Free CaM, CAMP and Ca2+/CaM-PK II Activity in Nerve Cells: Keqin XIE, et al. Institute of Toxicology, Shandong Medical University-Nerve cells in a culture from chicken embryo brain were used to study the allyl chloride-induced effects on the contents of intracellular Ca2+, Ca2+-free CaM, cAMP and the activity of Ca2+/CaM-PK II. The results showed that with the increase in the concentration of allyl chloride there was a significant increase in the content of Ca2+and cAMP, and the activity of Ca2+/CaM-PK II in the cells (P<0.01), but a marked decrease in Ca2+-free CaM (P<0.01). The results suggest that the neurotoxicity of allyl chloride might be related to the increase in intracellular Ca2+ and the activation of CaM and Ca2+/CaM-PK II, eventually leading to the accumulation of degenerative MT in the nerve axon.

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