Expression of Heme Oxygenase-1 in the Lungs of Rats Exposed to Potassium Octatitanate Whiskers
-
- Obata Yasuko
- Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
-
- Morimoto Yasuo
- Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
-
- Hirohashi Masami
- Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
-
- Ogami Akira
- Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
-
- Oyabu Takako
- Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
-
- Myojo Toshihiko
- Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
-
- Kawanami Shoko
- Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
-
- Horie Seichi
- Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
-
- Nagatomo Hiroko
- Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
-
- Murakami Masahiro
- Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
-
- Tanaka Isamu
- Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
Bibliographic Information
- Other Title
-
- Expression of Heme Oxygenase‐1 in the Lungs of Rats Exposed to Potassium Octatitanate Whiskers
Search this article
Abstract
Objectives: Oxidative stress is thought to be the pathogenesis of pulmonary fibrosis induced by asbestos, and heme oxygenase-1 (HO-1) protects lung tissue against oxidative stress. We hypothesized that HO-1 is also associated with oxidative lung injury caused by exposure to potassium octatitanate whiskers (PT1), which is one of the asbestos substitutes. Methods: Male Wistar rats were administered 1 mg or 2 mg PT1 suspended in saline by a single intratracheal instillation and were sacrificed after recovery for 3 days, 1 wk, 1 mo, 3 mo or 6 mo. Gene expression of HO-1 protein and mRNA and immunostaining were investigated in rat lungs. Results: HO-1 protein expression was increased from 3 days to 1 mo and at 6 mo in the 1 or 2 mg PT1-exposed groups, and the gene expression of HO-1 mRNA was also increased at 3 days and from 1 mo to 6 mo. HO-1-positive cells were mainly found in the alveolar macrophages and the bronchial epithelial cells in immunostaining. Conclusions: These findings suggest that HO-1 is involved in lung damage caused by PT1.<br>
Journal
-
- Journal of Occupational Health
-
Journal of Occupational Health 53 (4), 267-273, 2011
Japan Society for Occupational Health
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282679431647232
-
- NII Article ID
- 10029139731
- 130004447544
-
- NII Book ID
- AA11090645
-
- ISSN
- 13489585
- 13419145
-
- NDL BIB ID
- 11183680
-
- PubMed
- 21670561
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed