Memantine Alleviates Toxicity Induced by Dichlorvos in Rats
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- Zhou Zhijun
- School of Public Health, Fudan University
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- Dai Xufeng
- School of Public Health, Fudan University
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- Gu Xi'an
- School of Public Health, Fudan University
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- Sun Yunguang
- School of Public Health, Fudan University
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- Zheng Guang
- School of Public Health, Fudan University
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- Zheng Jie
- School of Public Health, Fudan University
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Abstract
The changes of N-methyl-D-aspartate (NMDA) receptor and protective efficacy of memantine (MEM) in rats poisoned with dichlorvos were studied. Dichlorvos evoked down-regulation of the affinity and density of [3H]MK-801 binding to NMDA receptor in the brain of rats receiving dichlorvos (15 and 25 mg/kg bw, i.p.). The binding capacity of NMDA receptor and acetylcholinesterase activity were determined at 4 h, 8 h, 16 h, 24 h and 48 h after treatment. When rats were given a different doses of MEM (5, 15 and 45 mg/kg bw) after poisoning (dichlorvos 25 mg/kg bw), the latency of onset of signs was postponed and the magnitude of muscular fasciculation was alleviated as the dose of MEM increased. The lower doses of MEM (5 and 15 mg/kg bw) could antagonize the dichlorvos-evoked down-regulation of NMDA receptor, while the highest dose (45 mg/kg bw) decreased the Bmax and Kd values of NMDA receptors. These results show the dichlorvos-evoked down-regulation of NMDA receptor might be self-regulation by the body to protect the central nervous system. MEM could antagonize the down-regulation of NMDA receptors, and alleviated signs of poisoning, especially reducing the magnitude of muscular fasciculation. We suggest that the role of NMDA receptor in organophosphates (OP) poisoning should receive more attention, and, that MEM treatment in acute OP poisoning, as a supplement to atropine and oxime, should be considered.<br>
Journal
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- Journal of Occupational Health
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Journal of Occupational Health 47 (2), 96-101, 2005
Japan Society for Occupational Health
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Keywords
Details 詳細情報について
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- CRID
- 1390282679432243840
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- NII Article ID
- 130004447272
- 110003723252
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- NII Book ID
- AA11090645
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- COI
- 1:CAS:528:DC%2BD2MXltFaks7o%3D
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- ISSN
- 13489585
- 13419145
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- NDL BIB ID
- 7294226
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- PubMed
- 15824473
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed