Urinary 1-hydroxypyrene and 8-hydroxydeoxyguanosine Levels among Coke-oven Workers for 2 Consecutive Days
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- Nguyen Thi-To-Uyen
- Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health Department of Social Medicine, Thai Nguyen University of Medicine and Pharmacy
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- Kawanami Shoko
- Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
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- Kawai Kazuaki
- Department of Environmental Oncology, Institute of Occupational and Industrial Ecological Sciences, University of Occupational and Environmental Health
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- Kasai Hiroshi
- Department of Environmental Oncology, Institute of Occupational and Industrial Ecological Sciences, University of Occupational and Environmental Health
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- Li Yun-Shan
- Department of Environmental Oncology, Institute of Occupational and Industrial Ecological Sciences, University of Occupational and Environmental Health
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- Inoue Jinro
- Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
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- Ngoan Le Tran
- Department of Occupational Health, Hanoi Medical University
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- Horie Seichi
- Department of Health Policy and Management, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
Bibliographic Information
- Other Title
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- Urinary 1‐hydroxypyrene and 8‐hydroxydeoxyguanosine Levels among Coke‐oven Workers for 2 Consecutive Days
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Abstract
Objectives: This study evaluated the levels of exposure to polycyclic aromatic hydrocarbons (PAHs) and their relationship with oxidative DNA damage among Vietnamese coke-oven workers. Methods: We collected urine from 36 coke-oven workers (exposed group) at the beginning and end of the shift on 2 consecutive days. We also collected urine from 78 medical staff (control group). Information was collected by questionnaire about smoking status, drinking habit, and working position. Urinary 1-hydroxypyrene (1-OHP) and 8-hydroxydeoxyguanosine (8-OH-dG) were measured using HPLC. All statistical analyses were performed with SPSS version 19. Results: Urinary 1-OHP was significantly higher in the coke-oven workers than in the control group (p<0.05). Top-oven workers had the highest levels of internal exposure to PAHs, followed by side-oven and then bottom-oven workers (5.41, 4.41 and 1.35 ng/mg creatinine, respectively, at the end of the shift on day 2). Urinary 8-OH-dG was significantly higher in top- and side-oven workers at the end of the shift on day 2 (4.63 and 5.88 ng/mg creatinine, respectively) than in the control group (3.85 ng/mg creatinine). Based on a multi-regression analysis, smoking status had a significant effect on urinary 8-OH-dG (p=0.049). Urinary 1-OHP tended to have a positive correlation with urinary 8-OH-dG (p=0.070). Conclusions: Vietnamese coke-oven workers were exposed to PAHs during their work shift. Urinary 1-OHP exceeded the recommended limit, and elevated oxidative DNA damage occurred in top- and side-oven workers on the second day of work. A tendency for positive correlation was found between urinary 1-OHP and urinary 8-OH-dG.(J Occup Health 2014; 56: 178-185)
Journal
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- Journal of Occupational Health
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Journal of Occupational Health 56 (3), 178-185, 2014
Japan Society for Occupational Health
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Details 詳細情報について
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- CRID
- 1390282679432459136
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- NII Article ID
- 130004447648
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- NII Book ID
- AA11090645
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- COI
- 1:CAS:528:DC%2BC2cXht1Kmtb%2FE
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- ISSN
- 13489585
- 13419145
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- NDL BIB ID
- 025490626
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- PubMed
- 24598053
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed