遺伝子工学・リモートセンシング・地理情報システムの技術を応用したヒトの環境適応能における遺伝-環境の相互作用解明への新研究法

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  • NEW APPROACHES TO DETECTING GENE-ENVIRONMENT INTERACTIONS IN ENVIRONMENTAL ADAPTABILITY USING GENETIC ENGINEERING, REMOTE SENSING AND GEOGRAPHIC INFORMATION SYSTEMS

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To gain a better understanding of the adaptive evolution of human skin pigmentation, we combined genetic engineering, remote sensing, and geographic information systems in a new approach for detecting gene-environment interactions. Previously, we detected natural selection on haplotypes of the OCA2 gene that had been revealed by SNP analyses. In this study, we analyzed ultraviolet radiation data obtained from satellite records. These results were subjected to a spatial statistical analysis technique for analyzing gene-environment interactions. The results suggested that skin color variations may be affected by mutations induced by ultraviolet radiation. These findings are consistent with the hypothesis that global variations in skin pigmentation may have resulted from localized adaptations to different ultraviolet radiation conditions via natural selection.

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