Neurological Disorders in Three Workers Exposed to 1-Bromopropane.
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- ICHIHARA Gaku
- Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
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- MILLER Joseph Keith
- Department of Neurology, Johnson Neurological Clinic
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- ZIOLKOKWSKA Aldona
- High Point Regional Hospital
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- ITOHARA Seiichiro
- Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
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- TAKEUCHI Yasuhiro
- Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
Bibliographic Information
- Other Title
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- Rapid Communication: Neurological Disorders in Three Workers Exposed to 1-Bromopropane
- Neurological Disorders in Three Workers Exposed to 1‐Bromopropane
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Abstract
A 35-yr-old female worker developed sore throat, stumbling, dysphagia, incontinence of urination and numbness with a burning sensation in the legs, thighs, hips and lower back as well as numbness in the perineum. She was spraying a glue to compose a cushion with polyurethane foam parts. One year after beginning to use a glue containing mainly 1-bromopropane, she became unable to stand up by herself. The second case, a 30-yr-old female worker developed a staggering gait, paresthesia, urinary incontinence, slurred voice, dysphagia, numbness or paresthesia in the hands, legs, lower back, hips and perineum, six months after beginning the same task. The third case, a 50-yr-old female worker showed signs of staggering, and numbness and paresthesias in the feet, thighs, lower back and hips, and headache, two months after starting the work. The daily time-weighted average of exposure concentrations ranged from 60 to 261 ppm (mean 133, N=11) after the ventilation was improved. The common signs in the three workers were staggering, numbness with paresthesia/dysesthesia, as well as a remarkable decrease in vibration sense in the legs and various symptoms in the central nervous system. Abnormal sensation was distributed to the area covered by pantyhose, rather than glove-stocking. Not only peripheral nerves, but also the spinal cord or brainstem was suspected to be impaired, given the paresthesia/dysesthesia and the distribution of sense deficits. Their diarrhea, incontinence of urination and abnormal sweating also suggested disorders in the autonomous nervous system. 1-Bromopropane might induce neurological disorders in the peripheral nerves and/or the central nervous system in humans.
Journal
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- Journal of Occupational Health
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Journal of Occupational Health 44 (1), 1-7, 2002
Japan Society for Occupational Health
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Details 詳細情報について
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- CRID
- 1390282679432992384
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- NII Article ID
- 130004447135
- 110003723186
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- NII Book ID
- AA11090645
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- DOI
- 10.1539/joh.44.1
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- ISSN
- 13489585
- 13419145
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- NDL BIB ID
- 6072069
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed