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Association between Paraoxonase 2 Gene Polymorphisms and Noise-induced Hearing Loss in the Chinese Population
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- Li Xiu-Ting
- Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control
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- Li Xin
- Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University
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- Hu Fei-Fei
- Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University
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- Shen Huan-Xi
- Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University
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- Cao Jing-Lian
- Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University
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- Li Zhong
- Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University
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- Zhang Zheng-Dong
- Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University
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- Zhu Bao-Li
- Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control
Bibliographic Information
- Other Title
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- Association between Paraoxonase 2 Gene Polymorphisms and Noise‐induced Hearing Loss in the Chinese Population
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Description
Objectives: The aim of the present study was to investigate whether PON2 gene polymorphisms (rs7493, rs12026, rs12704796, rs7785846 and rs7786401) are associated with susceptibility to noise-induced hearing loss (NIHL) in the Chinese population. Methods: A case-control study was conducted using 615 cases selected without any restriction in age or sex and 644 controls who were matched with the cases in terms of age, gender and the intensity and duration of exposure to noise. Information on these subjects was gathered by questionnaires that were administered through face-to-face interviews by trained interviewers. Results: We found that the rs7493 CG + GG genotype (OR=1.36, 95% CI, 1.08–1.72), rs12026 CG + GG genotype (OR=1.34, 95% CI, 1.06–1.70), rs7785846 CT + TT genotype (OR=1.36, 95% CI, 1.07–1.71) and rs7786401 GT + TT genotype (OR=1.33, 95% CI, 1.05–1.68) were risk factors for NIHL. Conclusions: PON2 gene polymorphisms may be associated with susceptibility to NIHL in the Chinese population.(J Occup Health 2013; 55: 56–65)
Journal
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- Journal of Occupational Health
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Journal of Occupational Health 55 (2), 56-65, 2013
Japan Society for Occupational Health
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Details 詳細情報について
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- CRID
- 1390282679433033600
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- NII Article ID
- 10031139895
- 130004447609
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- NII Book ID
- AA11090645
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- ISSN
- 13489585
- 13419145
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- NDL BIB ID
- 024384774
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- PubMed
- 23327886
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed