Association between Paraoxonase 2 Gene Polymorphisms and Noise-induced Hearing Loss in the Chinese Population

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  • Li Xiu-Ting
    Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control
  • Li Xin
    Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University
  • Hu Fei-Fei
    Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University
  • Shen Huan-Xi
    Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University
  • Cao Jing-Lian
    Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University
  • Li Zhong
    Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University
  • Zhang Zheng-Dong
    Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University
  • Zhu Bao-Li
    Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control

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  • Association between Paraoxonase 2 Gene Polymorphisms and Noise‐induced Hearing Loss in the Chinese Population

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Objectives: The aim of the present study was to investigate whether PON2 gene polymorphisms (rs7493, rs12026, rs12704796, rs7785846 and rs7786401) are associated with susceptibility to noise-induced hearing loss (NIHL) in the Chinese population. Methods: A case-control study was conducted using 615 cases selected without any restriction in age or sex and 644 controls who were matched with the cases in terms of age, gender and the intensity and duration of exposure to noise. Information on these subjects was gathered by questionnaires that were administered through face-to-face interviews by trained interviewers. Results: We found that the rs7493 CG + GG genotype (OR=1.36, 95% CI, 1.08–1.72), rs12026 CG + GG genotype (OR=1.34, 95% CI, 1.06–1.70), rs7785846 CT + TT genotype (OR=1.36, 95% CI, 1.07–1.71) and rs7786401 GT + TT genotype (OR=1.33, 95% CI, 1.05–1.68) were risk factors for NIHL. Conclusions: PON2 gene polymorphisms may be associated with susceptibility to NIHL in the Chinese population.(J Occup Health 2013; 55: 56–65)

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