Acute Arsine Poisoning Confirmed by Speciation Analysis of Arsenic Compounds in the Plasma and Urine by HPLC-ICP-MS
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- Yoshimura Yukihiro
- Department of Infectious Disease, Yokohama Municipal Citizen's Hospital
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- Endo Yoko
- Research Center for Occupational Poisoning, Kansai Rosai Hospital, Japan Labour Health and Welfare Organization
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- Shimoda Yasuyo
- Environmental Toxicology and Carcinogenesis Research Unit, Nihon University School of Pharmacy
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- Yamanaka Kenzo
- Environmental Toxicology and Carcinogenesis Research Unit, Nihon University School of Pharmacy
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- Endo Ginji
- Department of Preventive Medicine and Environmental Health, Graduate School of Medicine, Osaka City University
Bibliographic Information
- Other Title
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- Acute Arsine Poisoning Confirmed by Speciation Analysis of Arsenic Compounds in the Plasma and Urine by HPLC‐ICP‐MS
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Abstract
Objectives: Arsine, a potent hemolytic agent, is widely used in the semiconductor industry. We report a case of arsine poisoning confirmed by arsenic speciation analysis in serum and urine that occurred in a recycling factory. Case: A male worker in his twenties noticed hematuria 3 h after finishing work and was admitted into our hospital 34 h later. Speciation analysis of arsenics in serum and urine samples was performed using HPLC-ICP-MS. On admission, anemia, hematuria, and renal and liver dysfunction were observed. His clinical condition had improved remarkably after 5-days of transfusion and 4 units of RBC transfusion. The total arsenic content in the serum was 244.8 μg/l at admission and 97.1 μg/l at discharge. In the speciation analysis, four kinds of As compounds derived from arsine metabolism were detected in serum and urine. The concentrations of arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in serum at admission were 45.8, 5.2, 17.9 and 9.3 μg/l, respectively. The concentrations of AsIII, AsV and MMA decreased with biological half-lives (BHL) of 30.1, 43.0, and 96.3 h, respectively, while that of DMA was increased towards discharge. The urinary AsIII, AsV, MMA, and DMA concentrations at discharge were 384.5, 20.8, 547.4 and 1816.3 μg/g creatinine, respectively. These concentrations in urine subsequently decreased and their BHL was 15 days. Conclusion: The results of the present study suggest that arsine is quickly metabolized to AsIII and then metabolized via MMA to DMA in humans.<br>
Journal
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- Journal of Occupational Health
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Journal of Occupational Health 53 (1), 45-49, 2011
Japan Society for Occupational Health
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Details 詳細情報について
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- CRID
- 1390282679433328640
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- NII Article ID
- 10027417273
- 130004447527
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- NII Book ID
- AA11090645
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- COI
- 1:STN:280:DC%2BC3M3htFaruw%3D%3D
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- ISSN
- 13489585
- 13419145
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- NDL BIB ID
- 10958740
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- PubMed
- 21123960
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed