Effects of Platelet-Derived Growth Factor on Enhanced Bone Augmentation beyond the Skeletal Envelope within a Plastic Cap in the Rat Calvarium

DOI Web Site 被引用文献4件 参考文献13件
  • Tsuchiya Noriko
    Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry
  • Sato Shuichi
    Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry Department of Periodontology, Nihon University School of Dentistry
  • Kigami Risa
    Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry
  • Yoshimaki Tomohiro
    Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry
  • Arai Yoshinori
    Nihon University School of Dentistry
  • Ito Koichi
    Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry Department of Periodontology, Nihon University School of Dentistry

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We evaluated the ability of platelet-derived growth factor (PDGF) to promote bone augmentation beyond the skeletal envelope in rat calvarium. The calvaria of 14 rats were exposed and two plastic caps were placed with 0.03% or 0.01% PDGF with a collagen sponge (ACS) or ACS alone in the calvarium. Micro-CT and histological sections were used to obtain amount of bone augmentation within the plastic caps. Bone volume (BV) was calculated using BV-measuring software. The BV and amount of bone augmentation were significantly increased in the PDGF groups compared to the control groups after 4 weeks. However, there was no significant difference between the 0.03% and 0.01% PDGF groups. These results indicate that 0.03% and 0.01% PDGF in ACS enhance bone formation beyond the skeletal envelope in rat calvarium.

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