Proliferation, Stemness and Cardiac Differentiation Properties of Umbilical Cord Wharton^|^rsquo;s Jelly-derived Mesenchymal Stem Cells during the Continuous Passages

DOI Web Site 参考文献14件
  • Shi-jie Lv
    Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University Dalian Maternity Hospital
  • Liu Yang
    Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
  • Jian-chun Lian
    The Laboratory Medical College, Dalian Medical University
  • He Xin
    The Laboratory Medical College, Dalian Medical University
  • Liu Chang
    Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences University of Chinese Academy of Sciences
  • Guang-wei Sun
    Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
  • Guo Xin
    Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
  • Xiao-jun Ma
    Laboratory of Biomedical Material Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
  • Li Hui
    Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University

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  • Proliferation, Stemness and Cardiac Differentiation Properties of Umbilical Cord Wharton’s Jelly-derived Mesenchymal Stem Cells during the Continuous Passages

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Fetal tissue-derived mesenchymal stem cells (MSCs) may offer greater clinical utility because they possess unique properties over bone marrow (BM) MSCs. Although the continuous passage process can generate numerous MSCs for clinical applications, this process may also have an important effect on the bological characteristics of fetal MSCs. In this study, the proliferation, stemness and cardiac differentiation properties of umbilical cord (UC) Wharton’s Jelly-derived MSCs (WJ MSCs) at different passages (3, 7 and 14) was investigated. It was found that WJ MSC proliferation rate was decreased during the continuous passage process. And the ESC marker gene (Oct3/4, Nanog) expression in WJ MSCs also decreased gradually, while the early mesoderm marker gene (Vimentin) was highest at passage 7. Moreover, the cardiac marker gene (Nkx2.5) expression in differentiated MSCs increased during the continuous passage after cardiac induction. Our results may provide some useful information for stem cell therapy based on WJ MSCs.

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