Serum Nutritional Status of Tocopherol and Retinol Normalized to Lipids of Persons Living in the Southern Rural Terai Region in Nepal

DOI PubMed 1 Citations 57 References Open Access
  • HIRAI Kazuko
    Department of Health and Nutrition, Graduate School of Human Life Science, Osaka City University
  • OHNO Yoshimi
    Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women’s University
  • JINDAI Mayumi
    Department of Health and Nutrition, Graduate School of Human Life Science, Osaka City University
  • AOKI Yoko
    Department of Health and Nutrition, Graduate School of Human Life Science, Osaka City University
  • HAYASHI Eriko
    Department of Health and Nutrition, Graduate School of Human Life Science, Osaka City University
  • HIGUCHI Hisa
    Osaka Joshigakuen Junior College
  • MIZUNO Seiko
    Soai College
  • NAGATA Kumiko
    Department of Bacteriology, Hyogo College of Medicine, Nishinomiya
  • TAMURA Toshihide
    Department of Bacteriology, Hyogo College of Medicine, Nishinomiya
  • RAI Shiva K.
    Department of Microbiology, Nepal Medical College
  • SHRESTHA Mathura P.
    Department of Community Medicine and Public Health, Institute of Medicine, Tribhuvan University

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Objective: The present study examined the levels of serum α-Tocopherol (Toc), retinol (Ret), cholesterol (Chol) and triglycerides (TG), and their correlations in the sera of people in Nepal.<br> Methods: The survey was conducted on the general populace in the agricultural Terai region in southern Nepal. The study population consisted of 93 males and 83 females aged 10–68 years. Serum Toc and Ret were measured by high-performance liquid chromatography.<br> Results: No significant differences were observed between the genders for the average of total Chol (T-Chol) (140 and 145 mg/100 ml, respectively), HDL-C (45 and 47 mg/100 ml), LDL-C (94 and 97 mg/100 ml), and TG (106 and 110 mg/100 ml), and the ratio of LDL/HDL (2.16). The levels of mean Toc (4.32 and 4.27 μg/ml) were about the same for both genders, while the mean Ret levels were significantly higher for males (624 ng/ml) than for females (535 ng/ml) (p<0.001). A direct relationship was found between the levels of Toc and Ret (r=0.46, p<0.001 and r=0.28, p<0.05 for males and females, respectively). Serum levels of Toc and Ret were positively related to the levels of Chol (r=0.48 and r=0.58, p<0.001 for males and r=0.49, p<0.001 and r=0.33, p<0.01 for females, respectively) and TG (r=0.23 and r=0.28, p<0.05 for males and r=0.29, p<0.01 and r=0.28, p<0.05 for females, respectively). The ratio of Toc/TG normalized to serum TG was directly correlated to the ratio of Ret/TG (r=0.79 for males, and r=0.72 for females, p<0.001, respectively) and the ratios of Toc/TG and Ret/TG were negatively related to the LDL/HDL levels (r=−0.49 and r=−0.43, for males, and r=−0.46 and r=−0.57 for females, p<0.001, respectively).<br> Conclusion: The levels of Toc and Ret were low in the sera of people living in the southern rural Terai region in Nepal, and it was found that lower levels of Toc and Ret normalized to TG increased the ratio of LDL/HDL. These results suggest that greater intake of foods rich in Toc and Ret should be encouraged to reduce the risk of coronary heart disease.<br>

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