A New Graft Material for Mandibular Bone Defect Repair Using Regenerative Bone from Periosteum

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  • Mashimo Takayuki
    Division of Oral Structural and Functional Biology, Nihon University Graduate School of Dentistry Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry
  • Saito Tadahito
    Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry
  • Shiratsuchi Hiroshi
    Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry
  • Iwata Jun
    Division of Oral Structural and Functional Biology, Nihon University Graduate School of Dentistry Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry
  • Uryu Takeshi
    Division of Oral Structural and Functional Biology, Nihon University Graduate School of Dentistry Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry
  • Tamagawa Takaaki
    Division of Oral Structural and Functional Biology, Nihon University Graduate School of Dentistry Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry
  • Yasumitsu Tomohiro
    Division of Oral Structural and Functional Biology, Nihon University Graduate School of Dentistry Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry
  • Namaki Shunsuke
    Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry
  • Matsumoto Kunihito
    Department of Oral and Maxillofacial Radiology, Nihon University School of Dentistry
  • Mori Yoshiyuki
    Department of Oral and Maxillofacial Surgery, The University of Tokyo Hospital
  • Arai Yoshinori
    Nihon University School of Dentistry
  • Honda Kazuya
    Department of Oral and Maxillofacial Radiology, Nihon University School of Dentistry Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry
  • Yonehara Yoshiyuki
    Department of Oral and Maxillofacial Surgery, Nihon University School of Dentistry Division of Systemic Biology and Oncology, Dental Research Center, Nihon University School of Dentistry

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The objective of this study was to evaluate the usefulness of regenerative bone from periosteum as a new graft material for the repair of bone defects. Regenerative bone at 1, 4, and 8 weeks (RB1, RB4 and RB8) was harvested from the fibular periosteum of donor rats as graft materials. These regenerative bones were transplanted into the mandibular bone defects of recipient rats in the experimental groups (RB1, RB4 and RB8 groups). Normal fibulas (NF), which were harvested from donor rats, were transplanted in the control groups (NF groups). Immediately, 2, and 4 weeks after transplantation, radiological and histological findings were evaluated. Bone healing was observed in all groups. In particular, the height and width ratios in the RB1 groups were significantly higher than those in the NF groups, and RB1 resisted resorption as compared with the other bone grafts. The bone mineral density in the RB1 groups was significantly less than that in the NF groups. These results indicate that regenerative bone from periosteum is a useful reconstructive material. The properties of regenerative bone after transplantation differ depending on the timing of regeneration.

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