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Genotoxicity Study of Illegal Drug MDMA and Its Nitroso Derivative N-MDMA by Micronucleus and Chromosomal Aberration Tests using Chinese Hamster Lung Fibroblast Cell Line
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- YOSHIOKA Hayato
- Department of Public Health and Environmental Medicine, The Jikei University School of Medicine
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- SHIMIZU Hidesuke
- Department of Public Health and Environmental Medicine, The Jikei University School of Medicine
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- TOYAMA Yoshimitsu
- Department of Public Health and Environmental Medicine, The Jikei University School of Medicine Criminal Investigation Laboratory, Metropolitan Police Department
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- MIYAKOSHI Yuichi
- Department of Public Health and Environmental Medicine, The Jikei University School of Medicine
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- SUZUKI Yuji
- Department of Public Health and Environmental Medicine, The Jikei University School of Medicine
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- TAKAGI Ryo
- Department of Public Health and Environmental Medicine, The Jikei University School of Medicine
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Description
Objectives: An increase in incidence of the illegal use of tablets containing 3,4-methylenedioxymethamphetamine hydrochloride (MDMA) has recently become a widespread social problem. MDMA ingested orally reacts with nitrite in the stomach and is synthesized into N-nitroso-3,4-methylenedioxymethamphetamine (N-MDMA). The aim of this study is to investigate the genotoxic effects of MDMA and N-MDMA on the basis of the results of an in vitro micronucleus (MN) test and an in vitro chromosomal aberration (CA) test using a Chinese hamster lung fibroblast cell line (CHL/IU).<br> Methods: Tablets containing MDMA obtained from the Regional Bureau of the Ministry of Health, Labor and Welfare were purified, and N-MDMA was synthesized from MDMA in our laboratory. To evaluate the effects of MDMA and N-MDMA, the MN test established by our laboratory and the CA test in accordance with the guidelines for toxicity studies of drugs recommended by the Ministry of Health, Labor and Welfare were performed.<br> Results: In the MN test, no increased frequency of MNs was not found for MDMA. On the other hand, an apparently increased frequency of MNs was observed for N-MDMA. In the CA test, no CA was found for MDMA, but CA was observed for N-MDMA apparently.<br> Conclusion: N-MDMA genotoxicity was observed in the MN and CA tests. However, no MDMA genotoxicity was observed.<br>
Journal
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- Environmental Health and Preventive Medicine
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Environmental Health and Preventive Medicine 12 (3), 129-137, 2007
The Japanese Society for Hygiene
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Details 詳細情報について
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- CRID
- 1390282679434511872
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- NII Article ID
- 110006284967
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- NII Book ID
- AA1108348X
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- ISSN
- 13474715
- 1342078X
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- PubMed
- 21432066
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed