Should inflammatory pain and inflammation be attenuated by analgesics?

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  • HASEGAWA-MORIYAMA Maiko
    Department of Anesthesiology and Critical Care Medicine, Kagoshima University Graduate School of Medical and Dental Sciences

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  • 炎症性疼痛―炎症は抑えたほうがよいのか―
  • エンショウセイ トウツウ : エンショウ ワ オサエタ ホウ ガ ヨイ ノ カ

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<p>Inflammation is a defense response generated against invasion in order to maintain homeostasis, while pain is the sensation to avoid further damage and promote wound healing. Inflammatory pain often accompanies the chronic inflammatory state arising due to surgery, cancer, aging, and autoimmune diseases. Therefore, the approach towards inflammatory pain is to control pain without inhibiting inflammatory responses that are essential for defense. Since analgesics including nonsteroidal antiinflammatory drugs, opioids, and local anesthetics have immune-suppressive effects, their use may inhibit inflammation and delay the wound-healing process, further resulting in the development of chronic pain. Analgesics influence wound repair and can consequently lead to infections and progression towards cancer.</p>

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