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Geometry of artificial ECM Three-Dimensional Structure of Titanium-Web (TW) Promotes Differentiation of Human Bone Marrow Mesenchymal Cells into Osteoblasts
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- Li Dong
- School of Medicine, Sapporo Medical University
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- Iku Shouhei
- Koken Bioscience Institute
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- Nemoto Kazuki
- Koken Bioscience Institute
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- Kokai Yasuo
- School of Medicine, Sapporo Medical University
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- Odajima Tetsuya
- School of Medicine, Sapporo Medical University
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- Yoshimoto Ryota
- School of Dentistry, Health Sciences University of Hokkaido
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- Kaku Tohru
- School of Dentistry, Health Sciences University of Hokkaido
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- Katoh Hideki
- School of Dentistry, Health Sciences University of Hokkaido
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- Shiota Hiroyuki
- Medical Device Group, Nippon Cable System Inc.
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- Seki Yasuo
- Medical Device Group, Nippon Cable System Inc.
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- Ogura Naomi
- Nihon University School of Dentistry at Matsudo
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- Abiko Yoshimitsu
- Nihon University School of Dentistry at Matsudo
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- Kuboki Yoshinori
- School of Medicine, Sapporo Medical University Koken Bioscience Institute Graduate School of Dental Medicine, Hokkaido University
Bibliographic Information
- Other Title
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- Geometry of artificial ECM 3D structure of titanium web promotes differentiation of human bone marrow mesenchymal cells into osteoblasts
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Description
We demonstrate that a new culture system using a titanium web (TW) consisted of titanium fibers (50 mm diameter) can promote differentiation of mesenchymal cells into osteoblasts without conventional application of dexamethasone. Human mesenchymal stem cells (hMSC, Cambrex) and MC3T3-E1 were cultured on titanium web (87% of porosity). ALP/DNA in hMSC at 2 weeks was 2 times higher and MC3T3-E1 at 4 weeks was 4 times higher on TW than those on the conventional plastic dishes. Effect of 3D structure of TW is self-evident and the results will open a new age of 3D bone cell biology using TW.
Journal
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- Journal of Hard Tissue Biology
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Journal of Hard Tissue Biology 14 (2), 333-334, 2005
THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY
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Keywords
Details 詳細情報について
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- CRID
- 1390282679435352064
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- NII Article ID
- 110005853586
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- NII Book ID
- AA11074332
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- ISSN
- 1880828X
- 13417649
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed