Inhibitory Effect of Oligomeric Polyphenols from Peanut-skin on Sugar Digestion Enzymes and Glucose Transport

DOI Web Site 2 Citations 22 References Open Access
  • Tamura Tomoko
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • Ozawa Megumi
    Advantec.co.,ltd
  • Kobayashi Shoko
    Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • Watanabe Hirohito
    Department of Life Science and Department of Agricultural Chemistry, Meiji University
  • Arai Soichi
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
  • Mura Kiyoshi
    Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

Description

Inhibitory effects of oligomeric polyphenols extracted from peanut skin on α-amylase, maltase, sucrase and glucose transport were investigated. Epicatechin-(4β→6)-epicatechin-(2β→O→7, 4β→8)-catechin (EEC) as a procyanidin trimer inhibited α-amylase activity in a dose-dependent manner, while (+)-catechin and procyanidin A1 as a procyanidin dimer did not show any inhibitory activity up to 5 mg/mL. In the case of sucrase, EEC showed inhibitory activity stronger than (+)-catechin and procyanidin A1. Inhibitory effects of peanut skin on glucose transport in the small intestine were also investigated. The level of glucose transport in Caco-2 cells was significantly decreased by EEC compared to (+)-catechin. These results suggest that the inhibitory effects of procyanidins on α-amylase and α-glucosidase, and the suppression of intestinal glucose transport may change with the degree of polymerization.

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